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首页> 外文期刊>The Journal of Veterinary Medical Science >Analysis of the Mechanism of Reactivation of Latently Infecting Pseudorabies Virus by Acetylcholine
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Analysis of the Mechanism of Reactivation of Latently Infecting Pseudorabies Virus by Acetylcholine

机译:乙酰胆碱激活潜伏感染伪狂犬病病毒的机制分析

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摘要

In this study, the effect of cholinergic or adrenergic inhibitors on the reactivation of latent Pseudorabies virus (PRV) was analyzed to clarify the mechanism of the reactivation of latent PRY by acetylcholine. For acetylcholine inhibition, latently infected mice were injected with scopolamine or succynilcholine before acetylcholine stimulation. For sympathetic blocking, mice were preinjected intraperitoneally with phenoxybenzamine or propranolol. The signals to both acetylcholine receptors had no relationship to the reactivation of latent PRV, and both sympathetic blockers showed inhibition of PRV reactivation by acetylcholine. In our reactivation model, a large amount of acetylcholine may stimulate the sympathetic nerve system in some way to reactivate the virus.
机译:在这项研究中,分析了胆碱能或肾上腺素能抑制剂对潜伏性伪狂犬病病毒(PRV)的激活作用,以阐明乙酰胆碱对潜伏性PRY的激活机制。为了抑制乙酰胆碱,在乙酰胆碱刺激之前,向潜伏感染的小鼠注射东pol碱或磺基胆碱。对于交感神经阻滞,给小鼠腹膜内预先注射苯氧基苯扎明或普萘洛尔。两种乙酰胆碱受体的信号均与潜在PRV的再激活无关,两种交感神经阻滞剂均显示乙酰胆碱对PRV的抑制作用。在我们的激活模型中,大量的乙酰胆碱可能以某种方式刺激交感神经系统以重新激活病毒。

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