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首页> 外文期刊>Experimental Brain Research >Inhibitory and excitatory response areas of neurons in the central nucleus of the inferior colliculus in unanesthetized chinchillas
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Inhibitory and excitatory response areas of neurons in the central nucleus of the inferior colliculus in unanesthetized chinchillas

机译：未麻醉的龙猫下丘中央核神经元的抑制和兴奋反应区域

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摘要

In unanesthetized chinchillas, we determined excitatory and inhibitory response regions of neurons in the central nucleus of the inferior colliculus (ICc). The responses of 250 multiunits and 47 single units in the ICc to one- and two-tone stimuli were measured by extracellular recordings. The one-tone excitatory response area of ICc neurons from awake chinchillas was classified as either narrow with a steep high-frequency slope >140 dB/oct (type 1), broad with a high-frequency slope <140 dB/oct (type 2), or complex with a negative high-frequency slope (type 3). One-tone inhibition was prominent only in units with a high spontaneous firing rate. As revealed with two-tone stimuli, inhibition in the ICc of awake chinchillas and its relation to excitatory response regions was different from what is reported in anesthetized animals. The two-tone inhibitory responses were classified as follows: (1) inhibitory regions of equal strength on both sides of the characteristic frequency; (2) asymmetrical inhibitory regions, more prominent at the high-frequency side of the characteristic frequency; (3) strong inhibitory regions overlying most of the one-tone excitatory response region; (4) inhibitory response regions lying only within the one-tone excitatory response region; and (5) neurons without clear two-tone inhibition. One-tone and two-tone inhibitory regions of the same unit were markedly different in 66% of the units with a high spontaneous rate. The neural response to frequencies within the inhibitory regions often was an onset response followed by inhibition. Excitatory and inhibitory response properties were similar over considerable penetration distances (600–1,000 μm) in a particular dorso-ventral recording track.
机译：在未麻醉的龙猫中，我们确定了下丘（ICc）中央核中神经元的兴奋性和抑制性反应区域。通过细胞外记录测量ICc中的250个多单元和47个单个单元对一音和二音刺激的响应。来自清醒龙猫的ICc神经元的单调兴奋性反应区域被分类为：窄且高频斜率> 140 dB / oct（1型）宽，高频斜率<140 dB / oct（2型）宽）或具有负高频斜率的复数（类型3）。一音抑制仅在具有高自发发射率的单元中突出。如通过两个音调刺激所揭示的，清醒龙猫的ICc抑制及其与兴奋性反应区域的关系与麻醉动物中报道的有所不同。两种抑制反应的分类如下：（1）特征频率两侧强度相等的抑制区域； （2）不对称抑制区，在特征频率的高频侧更为突出； （3）覆盖大部分单调兴奋反应区的强抑制区； （4）抑制性反应区域仅位于一音兴奋性反应区域内； （5）没有明显的双音抑制作用的神经元。同一单元的一个音调和两个音调抑制区域在66％的单位中具有明显的自发性差异，自发率很高。对抑制区内频率的神经反应通常是起效反应，然后是抑制。在特定的背腹记录轨迹中，在相当大的穿透距离（600–1,000μm）内，兴奋和抑制反应的特性相似。

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