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Matrix Metalloproteinases Expression in Choroidal Neovascular Membranes

机译：脉络膜新生血管膜中基质金属蛋白酶的表达

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摘要

Purpose: To investigate the expression of matrix metalloproteinases (MMPs) in choroidal neovascular membranes with age-related macular degeneration (AMD). Methods: Seventeen choroidal neovascular membranes surgically removed from AMD patients with pars plana vitrectomy and subretinal membranes peeling were investigated. The expression of MMP-2 and MMP-9 was determined with immunohistochemical technique. Results: Immunohistochemistry staining in choroidal neovascular membranes for MMP-2 and MMP-9 was observed in 17 specimens. There was no detective of MMP-2 and MMP-9 in normal retinas. Conclusions: MMP-2 and MMP-9 were found in choroidal neovascular membranes, may degrade the Bruch membrane and be associated with the perforation of new vessels into Bruch membrane, involving a basic pathogenic process of AMD.
机译：目的：探讨基质金属蛋白酶（MMP）在年龄相关性黄斑变性（AMD）的脉络膜新生血管膜中的表达。方法：对经手术切除的伴有平面性玻璃体切除术和视网膜下膜剥离的AMD患者手术切除的十七个脉络膜新生血管膜进行了研究。用免疫组织化学方法检测MMP-2和MMP-9的表达。结果：在17个标本中观察到脉络膜新生血管膜中MMP-2和MMP-9的免疫组织化学染色。在正常视网膜中未检测到MMP-2和MMP-9。结论：脉络膜新生血管膜中存在MMP-2和MMP-9，可能降解Bruch膜，并与新血管穿孔进入Bruch膜有关，涉及AMD的基本致病过程。

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