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首页> 外文期刊>Food microbiology >Quantification and genetic diversity of Hepatitis E virus in wild boar (Sus scrofa) hunted for domestic consumption in Central Italy
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Quantification and genetic diversity of Hepatitis E virus in wild boar (Sus scrofa) hunted for domestic consumption in Central Italy

机译：在意大利中部寻找家庭消费的野猪中的戊型肝炎病毒的定量和遗传多样性

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摘要

Hepatitis E is an emerging disease in industrialized countries. The food-borne transmission of hepatitis E virus (HEV) is associated principally with products derived from the domestic pig, the wild boar, and deer; however, few quantitative data are available on HEV loads in animals used in food production. This study assessed HEV occurrence, viral load and genetic variability in wild boar hunted for domestic consumption in the district of Viterbo (Central Italy) where high anti-HEV IgG seroprevalence values are reported in humans. A total of 332 liver and 69 intestine samples were obtained from wild boar hunted between 2011 and 2014. The liver tissue in 54 of the animals (16.3%) was HEV-positive. Viral loads in quantifiable liver samples (n=29) ranged between 3.2x10(2) and 3.8x10(5) genome copies (g.c.)/g with a mean value of 1.85x10(4) g.c./g. A statistically significant positive correlation was found between viral concentration in liver and intestinal tissue, though mean viral load in the intestines was lower (3.13x10(3) g.c./g). Twenty-six samples were characterized molecularly as genotype 3 (G3) and four subtypes (a, c, f and l) were detected. Finally, twelve samples with near identical sequences were identified as G3 but could not be assigned to any of the known subtypes, and could therefore represent a potentially new subtype.
机译：戊型肝炎是工业化国家中的一种新兴疾病。戊型肝炎病毒（HEV）的食源性传播主要与家猪，野猪和鹿的产品有关。但是，关于用于食品生产的动物中HEV负荷的定量数据很少。这项研究评估了在维特博（意大利中部）被捕食供国内消费的野猪中的戊型肝炎病毒的发生，病毒载量和遗传变异性，该地区据报道人类体内抗-HEV IgG血清阳性率较高。从2011年至2014年之间猎取的野猪共获得332个肝脏和69个肠道样本。其中54个动物（16.3％）的肝组织为HEV阳性。可量化肝样本（n = 29）中的病毒载量范围为3.2x10（2）和3.8x10（5）基因组拷贝（g.c。）/ g，平均值为1.85x10（4）g.c./g。尽管肠道中的平均病毒载量较低（3.13x10（3）g.c./g），但肝脏和肠道组织中的病毒浓度之间存在统计学上的显着正相关。 26个样品的分子特征为基因型3（G3），并检测到四个亚型（a，c，f和l）。最后，十二个具有几乎相同序列的样本被标识为G3，但无法分配给任何已知的亚型，因此可以代表潜在的新亚型。

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  • 来源
    《Food microbiology》 |2019年第9期|194-201|共8页
  • 作者

    Di Pasquale Simona; De Santis Paola; La Rosa Giuseppina; Di Domenico Kevin; Iaconelli Marcello; Micarelli Giuseppe; Martini Enrica; Bilei Stefano; De Medici Dario; Suffredini Elisabetta;

  • 作者单位

    Ist Super Sanita, Dept Food Safety Nutr & Vet Publ Hlth, Viale Regina Elena 299, I-00161 Rome, Italy;

    Ist Zooprofilatt Sperimentale Lazio & Toscana M A, Via Appia Nuova 1411, I-00178 Rome, Italy;

    Ist Super Sanita, Dept Environm & Hlth, Viale Regina Eiena 299, I-00161 Rome, Italy;

    Ist Super Sanita, Dept Food Safety Nutr & Vet Publ Hlth, Viale Regina Elena 299, I-00161 Rome, Italy;

    Ist Super Sanita, Dept Environm & Hlth, Viale Regina Eiena 299, I-00161 Rome, Italy;

    Local Hlth Dept Viterbo, Vet Off, Via Dante Alighieri 100, I-01027 Montefiascone, VT, Italy;

    Local Hlth Dept Viterbo, Vet Off, Via Dante Alighieri 100, I-01027 Montefiascone, VT, Italy;

    Ist Zooprofilatt Sperimentale Lazio & Toscana M A, Via Appia Nuova 1411, I-00178 Rome, Italy;

    Ist Super Sanita, Dept Food Safety Nutr & Vet Publ Hlth, Viale Regina Elena 299, I-00161 Rome, Italy;

    Ist Super Sanita, Dept Food Safety Nutr & Vet Publ Hlth, Viale Regina Elena 299, I-00161 Rome, Italy;

  • 收录信息 美国《科学引文索引》(SCI);美国《化学文摘》(CA);
  • 原文格式 PDF
  • 正文语种 eng
  • 中图分类
  • 关键词

    Hepatitis E virus; HEV; Wild boar; Foodborne transmission; Risk assessment; Typing;

    机译：戊型肝炎病毒;戊型肝炎病毒;野猪;食源性传播;风险评估;分型;

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