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Glutathione improves the cold resistance of Lactobacillus sanfranciscensis by physiological regulation

机译：谷胱甘肽通过生理调节提高三乳酸杆菌的抗寒性

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摘要

The microenvironmental manipulation of glutathione (GSH) on improving cold resistance of Lactobacillus sanfranciscensis DSM 20451~T was investigated in this study. It was proved that GSH relieves the metabolic disorder of cells under cold stress, and prevents the decreased activities of related key enzymes such as pyruvate kinase (PK), glyceraldehyde-3-phosphate dehydrogenase (GAPDH) and lactate dehydrogenase (LDH) upon cold challenges. Higher intracellular ATP level was also found in cells with GSH under cold stress. Moreover, cells with imported GSH had significantly higher intracellular than the control during cold treatment. In addition, proteomics analysis showed more exciting findings that the protective function of GSH under cold stress was related to metabolic regulation and the multi-control against induced cross-stresses. These results broaden the knowledge about the physiological function of GSH, and suggest a practicable approach to improve the cold resistance of L sanfranciscensis, a starter culture for sourdough, by the addition of GSH.
机译：本研究研究了谷胱甘肽（GSH）在提高旧金山乳杆菌DSM 20451〜T抗寒性中的微环境操作。事实证明，谷胱甘肽过氧化物酶（GSH）缓解了寒冷胁迫下的细胞代谢紊乱，并防止了寒冷挑战时丙酮酸激酶（PK），3-磷酸甘油醛脱氢酶（GAPDH）和乳酸脱氢酶（LDH）等相关关键酶活性的降低。 。在冷应激下，谷胱甘肽过氧化物酶细胞也发现较高的细胞内ATP水平。而且，在冷处理期间，具有进口的GSH的细胞具有比对照明显更高的细胞内。此外，蛋白质组学分析显示了更多令人振奋的发现，即冷应激下谷胱甘肽的保护功能与代谢调节和对抗交叉应激的多重控制有关。这些结果拓宽了关于GSH生理功能的知识，并提出了一种可行的方法，通过添加GSH来提高发酵酵母发酵液L Sanfranciscensis的耐寒性。

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  • 来源
    《Food microbiology》 |2012年第2期|p.285-292|共8页
  • 作者

    Juan Zhang; Yin Li; Wei Chen; Guo-Cheng Du; Jian Chen;

  • 作者单位

    State Key Laboratory of Food Science and Technology, Jiangnan University, China,School of Biotechnology, Jiangnan University, China;

    Institute of Microbiology, Chinese Academy of Sciences, China;

    School of Food Science and Technology, Jiangnan University, China;

    State Key Laboratory of Food Science and Technology, Jiangnan University, China,School of Biotechnology, Jiangnan University, China,State Key Laboratory of Food Science and Technology,Jiangnan University, 1800 Lihu Road, Wuxi 214122, China;

    School of Biotechnology, Jiangnan University, China,National Engineering Laboratory for Cereal Fermentation Technology, Jiangnan University, 1800 Lihu Road, Wuxi 214122,China;

  • 收录信息 美国《科学引文索引》(SCI);美国《化学文摘》(CA);
  • 原文格式 PDF
  • 正文语种 eng
  • 中图分类
  • 关键词

    lactobacillus sanfranciscensis; glutathione; cold stress; metabolic regulation; proteomics analysis;

    机译：旧金山乳酸杆菌;谷胱甘肽;冷应激;代谢调节;蛋白质组学分析;

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