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Lack of association between IRAK2 genetic variants and aspirin exacerbated respiratory disease

机译：IRAK2基因变异与阿司匹林加重呼吸系统疾病之间缺乏关联

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Asthma is a global health problem which threatens approximately 300 million patients worldwide. Among them, up to 20 % of the asthma patients are classified as aspirin exacerbated respiratory disease (AERD). Interleukin-1 receptor associated kinase (IRAK2) is associated with necrosis factor kappa B (NF-кB) pathway via interleukin-1 (IL-1) signaling. NF-кB pathway is known to be involved in asthma development, and several interleukin and IRAK family members have also been reported to be associated with asthma or AERD. Since IRAK2 plays an important role in the asthma etiology, we hypothesized that the genetic variants of IRAK2 may be associated with AERD. This study genotyped a total of 25 common single nucleotide polymorphisms (SNPs) in 163 AERD cases and 429 aspirin-tolerant asthma (ATA) controls. As a result, no significant association was found between the genetic variants of IRAK2 and AERD (P > 0.05). In further regression analysis for the forced expiratory volume in 1 s (FEV1) decline, an important phenotype for diagnosing AERD, although one haplotype (BL1_ht3) showed a nominal association with FEV1 decline (P = 0.04), the significance disappeared after correction for multiple testing (P > 0.05). Despite limitations in our study and need for replications, our results suggest that the genetic variants of IRAK2 might not be associated with AERD and the obstructive symptoms in asthma.
机译：哮喘是全球性的健康问题，威胁着全球约3亿患者。其中，多达20％的哮喘患者被分类为阿司匹林加重性呼吸系统疾病（AERD）。白介素-1受体相关激酶（IRAK2）通过白介素-1（IL-1）信号传导与坏死因子κB（NF-кB）途径相关。已知NF-кB通路与哮喘的发展有关，据报道，一些白介素和IRAK家族成员也与哮喘或AERD相关。由于IRAK2在哮喘病因中起着重要作用，因此我们假设IRAK2的遗传变异可能与AERD相关。这项研究对163例AERD病例和429例阿司匹林耐受性哮喘（ATA）对照人群中的25种常见单核苷酸多态性（SNP）进行了基因分型。结果，IRAK2和AERD的遗传变异之间未发现显着关联（P> 0.05）。在进一步的1s强迫呼气量下降（FEV1）回归分析中，这是诊断AERD的重要表型，尽管一种单倍型（BL1_ht3）与FEV1下降呈名义相关性（P = 0.04），但在校正了多个测试（P> 0.05）。尽管我们的研究存在局限性并且需要重复研究，但我们的结果表明IRAK2的遗传变异可能与AERD和哮喘的阻塞性症状无关。

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