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首页> 外文期刊>Growth, Development, & Aging >Effects of Pre and Antenatal Elevated and Chronic oMtla-oGH Transgene Expression on Adipose Deposition and Linear Bone Growth in Mice.
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Effects of Pre and Antenatal Elevated and Chronic oMtla-oGH Transgene Expression on Adipose Deposition and Linear Bone Growth in Mice.

机译:产前和产前升高和慢性oMtla-oGH转基因表达对小鼠脂肪沉积和线性骨生长的影响。

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摘要

Exposing growing oMt1a-oGH trans- genic mice with the regulatable metallothionein promotor to elevated growth hormone (GH) for three weeks after weaning enhances bone length and adipocyte differentiation. The objective of the present study was to investigate the consequences of highly elevated GH exposure during fetal and early postnatal growth periods on the mature phe- notype. Transgene expression, hence elevated GH, was achieved in fetuses and neonates by providing 25 mM ZnSO_4 to the drinking water of the dams.
机译:断奶后将生长中的带有可调节金属硫蛋白启动子的oMt1a-oGH转基因小鼠暴露于升高的生长激素(GH)中三周,可延长骨长和脂肪细胞分化。本研究的目的是研究胎儿和出生后早期生长激素暴露水平升高对成熟表型的影响。通过向大坝的饮用水提供25 mM ZnSO_4,可在胎儿和新生儿中实现转基因表​​达,从而提高GH。

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