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Florida red tide toxins (brevetoxins) and longitudinal respiratory effects in asthmatics

机译：佛罗里达红潮毒素（brevetoxins）和哮喘患者的纵向呼吸作用

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摘要

Having demonstrated significant and persistent adverse changes in pulmonary function for asthmatics after 1 h exposure to brevetoxins in Florida red tide {Karenia brevis bloom) aerosols, we assessed the possible longer term health effects in asthmatics from intermittent environmental exposure to brevetoxins over 7 years. 125 asthmatic subjects were assessed for their pulmonary function and reported symptoms before and after 1 h of environmental exposure to Florida red tide aerosols for up to 11 studies over seven years. As a group, the asthmatics came to the studies with normal standardized percent predicted pulmonary function values. The 38 asthmatics who participated in only one exposure study were more reactive compared to the 36 asthmatics who participated in >4 exposure studies. The 36 asthmatics participating in >4 exposure studies demonstrated no significant change in their standardized percent predicted pre-exposure pulmonary function over the 7 years of the study. These results indicate that stable asthmatics living in areas with intermittent Florida red tides do not exhibit chronic respiratory effects from intermittent environmental exposure to aerosolized brevetoxins over a 7 year period.
机译：暴露于佛罗里达赤潮（Karenia brevis bloom）气溶胶中的短毒素后，哮喘患者的肺功能出现了明显且持续的不利变化，我们评估了间歇性环境暴露于短毒素7年来对哮喘患者的长期健康影响。对125名哮喘受试者的肺功能进行了评估，并报告了在7年内进行的11项研究中，在环境暴露于佛罗里达赤潮气溶胶1小时之前和之后的症状。作为一组，哮喘患者以正常的标准百分比预测肺功能值进入研究。与参加> 4次暴露研究的36名哮喘患者相比，仅参加一项暴露研究的38名哮喘患者反应性更高。参与> 4次暴露研究的36名哮喘患者在研究的7年中显示，其标准化的预测暴露前肺功能百分比无明显变化。这些结果表明，居住在佛罗里达州赤潮间歇地区的稳定哮喘患者，在7年的时间里，由于间歇性环境暴露于雾化的短毒素而不会表现出慢性呼吸作用。

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  • 来源
    《Harmful Algae》 |2011年第6期|p.744-748|共5页
  • 作者

    Judy A. Bean; Lora E. Fleming; Barbara Kirkpatrick; Lorraine C. Backer; Kate Nierenberg; Andrew Reich; Yung Sung Cheng; Adam Wanner; Janet Benson; Jerome Naar; Richard Pierce; William M. Abraham; Gary Kirkpatrick; Julie Hollenbeck; Julia Zaias; Eliana Mendes; Daniel G. Baden;

  • 作者单位

    Children's Hospital Medical Center and University of Cincinnati, Cincinnati, OH 45229, United States;

    JVSF NIEHS Oceans and Human Health Center, University of Miami, 4600 Rickenbacker Causeway, Miami, FL 33149, United States, European Centre for Environment and Human Health (ECEHH), Peninsula College of Medicine and Dentistry, Knowledge Spa, Royal Cornwall Hospital, Truro, Cornwall TR1 3HD, UK,Dept of Epidemiology and Public Health, Miller School of Medicine, University of Miami, Miami, FL 33136, United States;

    Mote Marine Laboratory, 1600 Ken Thompson Parkway, Sarasota, FL 34236, United States;

    National Center for Environmental Health, Centers for Disease Control and Prevention, 4770 Buford Highway NE, Chamblee, CA 30341, United States;

    Mote Marine Laboratory, 1600 Ken Thompson Parkway, Sarasota, FL 34236, United States;

    Florida Department of Health, 4052 Bald Cypress Way, Tallahassee, FL 32399, United States;

    Lovelace Respiratory Institute, 2425 Ridgecrest, SE Albuquerque, NM 87108, United States;

    Dept of Medicine (Division of Pulmonary Medicine), Miller School of Medicine, University of Miami, Miami, FL 33136, United States;

    Lovelace Respiratory Institute, 2425 Ridgecrest, SE Albuquerque, NM 87108, United States;

    Center for Marine Science, University of North Carolina, 5600 Marvin K. Moss Lane, Wilmington, NC 28409, United States;

    Mote Marine Laboratory, 1600 Ken Thompson Parkway, Sarasota, FL 34236, United States;

    Dept of Medicine (Division of Pulmonary Medicine), Miller School of Medicine, University of Miami, Miami, FL 33136, United States,Department of Research, Mount Sinai Medical Center, Miami Beach, FL, United States;

    Mote Marine Laboratory, 1600 Ken Thompson Parkway, Sarasota, FL 34236, United States;

    JVSF NIEHS Oceans and Human Health Center, University of Miami, 4600 Rickenbacker Causeway, Miami, FL 33149, United States;

    Dept of Pathology, Miller School of Medicine, University of Miami, FL 33136, United States;

    Dept of Medicine (Division of Pulmonary Medicine), Miller School of Medicine, University of Miami, Miami, FL 33136, United States;

    Center for Marine Science, University of North Carolina, 5600 Marvin K. Moss Lane, Wilmington, NC 28409, United States;

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  • 正文语种 eng
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  • 关键词

    asthma; harmful algal bloom (HAB); karenia brevis; longitudinal health study;

    机译：哮喘;有害藻华（HAB）;凯里尼亚·布雷维斯纵向健康研究;

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