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首页> 外文期刊>IEE Proceedings. Part M, Nanobiotechnology >Nanofluidic channels fabrication and manipulation of DNA molecules
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Nanofluidic channels fabrication and manipulation of DNA molecules

机译：DNA分子的纳米流体通道的制造和操作

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Nanofluidic channel arrays, which have a width of about 40 nm, depth of 60 nm and length of 50 (mu)m, were created using a focused-ion-beam milling instrument on a silicon nitride film swiftly and exactly, as is necessary. Stained lambda-DNA molecules were put inside these sub-100 nm conduits by capillary force and they were stretched and transferred along these conduits, which were dealt with activating reagent Brij aqueous solution in advance. The movements of DNA molecules in these channels were discussed. These nano-structure channels may be useful in the study and analysis of the statics as well as the dynamics of single biomolecules.
机译：使用聚焦离子束研磨仪在必要时迅速，准确地在氮化硅膜上创建了宽度约为40 nm，深度为60 nm，长度为50μm的纳米流体通道阵列。将染色的λ-DNA分子通过毛细作用力放入这些100 nm以下的导管中，并沿这些导管拉伸和转移，并事先用活化剂Brij水溶液处理。讨论了DNA分子在这些通道中的运动。这些纳米结构通道可用于研究和分析单个生物分子的静力学以及动力学。

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