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首页> 外文期刊>IEEE transactions on circuits and systems . I , Regular papers >An Integrated System for Simultaneous, Multichannel Neuronal Stimulation and Recording
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An Integrated System for Simultaneous, Multichannel Neuronal Stimulation and Recording

机译：同时，多通道神经元刺激和记录的集成系统。

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Precision electronics that provide multi-electrode stimulation and recording capabilities are an important tool for the experimental study of neuronal development and plasticity. Towards this end, we present a custom analog integrated circuit (IC), fabricated in a 0.35-mum process, incorporating stimulation buffers and recording preamplifiers for multiple electrodes onto a single die. The architecture of the IC allows for arbitrary, independent configuration of electrodes for stimulation or recording, and the IC includes artifact-elimination circuitry that returns the stimulation electrode to its previous voltage following stimulation, minimizing the interference with recording. We analyze the thermal noise levels in the recording preamplifiers and experimentally measure input-referred noise as low as 4.77 muVrms in the frequency range of 30 Hz-3 kHz at a power consumption of 100 muW from a total power supply of 3.8 V. We also consider the temporal response and stability of the artifact elimination circuitry. We demonstrate that the use of the artifact-elimination circuitry with a 30-mum diameter stimulation electrode permits a return to recording mode in les 2 ms after stimulation, facilitating near-simultaneous stimulation and recording of neuronal signals. (Patent applied for, U.S. No. 2007/0178579.)
机译：提供多电极刺激和记录功能的精密电子设备是神经元发育和可塑性实验研究的重要工具。为此，我们提出了一种定制的模拟集成电路（IC），该集成电路采用0.35微米工艺制造，将刺激缓冲液和用于多个电极的前置放大器记录到单个芯片上。 IC的架构允许用于刺激或记录的电极的任意独立配置，并且IC包含伪像消除电路，该伪像消除电路可在刺激后将刺激电极恢复至先前的电压，从而最大程度地减少了对记录的干扰。我们分析了记录前置放大器中的热噪声水平，并通过从总电源3.8 V消耗100μW的功率，在30 Hz-3 kHz的频率范围内实验测量了低至4.77μVrms的输入参考噪声。考虑伪影消除电路的时间响应和稳定性。我们证明了使用带有30毫米直径刺激电极的人工信号消除电路，可以在刺激后2毫秒内恢复到记录模式，从而促进近同时刺激和神经信号的记录。 （专利申请号：2007/0178579。）

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