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首页> 外文期刊>IEEE Transactions on Ultrasonics, Ferroelectrics, and Frequency Control >Targeted Lesion Generation Through the Skull Without Aberration Correction Using Histotripsy
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Targeted Lesion Generation Through the Skull Without Aberration Correction Using Histotripsy

机译：通过颅骨靶向病变的产生，而无需使用组织畸变进行像差校正

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摘要

This study demonstrates the ability of histotripsy to generate targeted lesions through the skullcap without using aberration correction. Histotripsy therapy was delivered using a 500-kHz 256-element hemispherical transducer with an aperture diameter of 30 cm, and a focal distance of 15 cm fabricated in our laboratory. This transducer is theoretically capable of producing peak rarefactional pressures, based on linear estimation, (p-), in the free field in excess of 200 MPa with pulse durations 2 acoustic cycles. Three excised human skullcaps were used displaying attenuations of 73%–81% of the acoustic pressure without aberration correction. Through all three skullcaps, compact lesions with radii less than were generated in red blood cell agarose tissue phantoms without aberration correction, using estimated (p-) of , a pulse repetition frequency of , and a total number of 300 pulses. Lesion generation was consistently observed at the geometric focus of the transducer as the position of the skullcap with respect to the transducer was varied, and multiple-patterned lesions were generated transcranially by mechanically adjusting the position of the skullcap with respect to the transducer to target different regions within. These results show that compact targeted lesions with sharp boundaries can be generated through intact skullcaps using histotripsy with very short pulses without using aberration correction. Such capability has the potentia- to greatly simplify transcranial ultrasound therapy for noninvasive transcranial applications, as current ultrasound transcranial therapy techniques all require sophisticated aberration correction.
机译：这项研究证明了在不使用像差校正的情况下，组织曲张通过黄the产生目标病变的能力。使用我们实验室中制造的孔径为30 cm，焦距为15 cm的500 kHz 256元素半球形换能器进行组织肌疗法。该换能器理论上能够基于线性估计（p-）在超过200 MPa的自由场中以脉冲持续时间2个声波周期产生峰值稀疏压力。使用了三个切除的人类黄skull，在没有像差校正的情况下衰减了73％–81％的声压。在所有三个无边帽中，使用估计的（p-）为，脉冲重复频率为，总数为300个脉冲，在不进行像差校正的情况下，在红细胞琼脂糖组织模型中产生了半径小于在半径范围内的紧凑型病变。随着黄cap相对于传感器的位置的变化，在换能器的几何焦点处始终观察到病变的产生，并且通过机械地调整黄cap相对于换能器的位置以跨目标地通过颅骨产生多模式病变内的区域。这些结果表明，可以通过使用非常短的脉冲的组织变性术通过完整的黄cap产生具有清晰边界的紧凑的靶向病变，而无需使用像差校正。这种能力具有极大地简化无创经颅应用中经颅超声治疗的潜力，因为当前的超声经颅治疗技术都需要复杂的像差校正。

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