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Motion artifact reduction in ultrasound based thermal strain imaging of atherosclerotic plaques using time-series analysis

机译:使用时间序列分析在基于超声的动脉粥样硬化斑块热应变成像中减少运动伪影

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摘要

Large lipid pools in vulnerable plaques, in principle, can be detected using ultrasound-based thermal strain imaging (US-TSI). One practical challenge for in vivo cardiovascular application of US-TSI is that the thermal strain is masked by the mechanical strain caused by cardiac pulsation. Electrocardiography (ECG) gating is a widely adopted method for cardiac motion compensation, but it is often susceptible to electrical and physiological noise. In this paper, we present an alternative time-series analysis approach to separate thermal strain from the mechanical strain without using ECG. The performance and feasibility of the time-series analysis technique was tested via numerical simulation as well as in vitro water tank experiments, using a vessel-mimicking phantom and an excised human atherosclerotic artery, for which the cardiac pulsation is simulated by a pulsatile pump.
机译:原则上,可以使用基于超声的热应变成像(US-TSI)来检测易损斑块中的大脂质池。 US-TSI在体内心血管应用中的一个实际挑战是,热应变被心脏搏动引起的机械应变所掩盖。心电图(ECG)门控是一种广泛采用的用于心脏运动补偿的方法,但它通常容易受到电和生理噪声的影响。在本文中,我们提出了一种替代的时间序列分析方法,以在不使用ECG的情况下将热应变与机械应变分开。时间序列分析技术的性能和可行性通过数值模拟以及体外水箱实验进行了测试,使用了模拟血管的模型和已切除的人类动脉粥样硬化动脉,并通过脉动泵模拟了心脏的搏动。

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