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Motion artifact reduction for IVUS-based thermal strain imaging

机译:基于IVUS的热应变成像的运动伪影减少

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Thermal strain imaging (TSI) using intravascular ultrasound (IVUS) has the potential to identify lipid pools within rupture-prone arterial plaques and serve as a valuable supplement to current IVUS systems in diagnosing acute coronary syndromes. The major challenge for in vivo application of TSI will be cardiac motion, including bulk motion and tissue deformation. Simulations based on an artery model, including a lipid-filled plaque, demonstrate that effective bulk motion compensation can be achieved within a certain motion range using spatial interpolation. We also propose a practical imaging scheme to minimize mechanical strains caused by tissue deformation based on a linear least squares fitting strategy. This scheme was tested on clinical data by artificially superimposing thermal displacements corresponding to different temperature rises. Results suggest a 1-2/spl deg/C temperature rise is required to detect lipids in an atherosclerotic plaque in vivo.
机译:使用血管内超声(IVUS)的热应变成像(TSI)具有识别易破裂动脉斑块内脂质库的潜力,并可以作为当前IVUS系统在诊断急性冠状动脉综合征中的宝贵补充。体内应用TSI的主要挑战将是心脏运动,包括整体运动和组织变形。基于动脉模型(包括充满脂质的斑块)的仿真表明,使用空间插值可以在特定运动范围内实现有效的整体运动补偿。我们还提出了一种实用的成像方案,以最小化基于线性最小二乘拟合策略的由组织变形引起的机械应变。通过人工叠加对应于不同温升的热位移,对该方案进行了临床数据测试。结果表明,在体内检测动脉粥样硬化斑块中的脂质需要1-2 / spl deg / C的温度升高。

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