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首页> 外文期刊>IEEE Transactions on Ultrasonics, Ferroelectrics, and Frequency Control >Techniques for perfusion imaging with microbubble contrast agents
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Techniques for perfusion imaging with microbubble contrast agents

机译：微泡造影剂的灌注成像技术

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摘要

The acoustic properties of ultrasound contrast agents vary widely with agent composition and insonation conditions. For contrast imaging, methods are required to match RF and Doppler processing to each combination of transmission parameters and agent and tissue properties. We propose a method that uses the measured or modeled echoes from agent and tissue to specify directly the characteristics of RF and Doppler filters for contrast imaging. The proposed method is sufficiently general to cover most common imaging techniques including harmonic greyscale, Doppler, and pulse inversion imaging. Using this method, sample filters were designed to detect myocardial perfusion with the contrast agent Optison/sup TM/ (Mallinckrodt Medical, St. Louis, MO) under selected imaging conditions. Simplified power Doppler filtering, using a weighted sum of the Doppler samples, matched the performance of more complicated matrix filters. By coordinating the selection of RF and Doppler filters rather than designing these filters sequentially, agent-to-tissue contrast was increased by up to 3.9 dB. Under some conditions, fundamental RF filtering outperformed harmonic filtering for intermittent Doppler imaging.
机译：超声造影剂的声学特性随试剂成分和声波条件的不同而有很大差异。对于造影剂成像，需要使用方法将RF和多普勒处理与传输参数以及药物和组织特性的每种组合相匹配。我们提出了一种方法，该方法使用来自代理和组织的已测量或建模的回波来直接指定用于对比成像的RF和多普勒滤波器的特征。所提出的方法具有足够的通用性，可以涵盖最常见的成像技术，包括谐波灰度，多普勒和脉冲反转成像。使用这种方法，设计了样品过滤器，以在选定的成像条件下用造影剂Optison / sup TM /（Mallinckrodt Medical，圣路易斯，密苏里州）检测心肌灌注。使用多普勒样本的加权总和的简化功率多普勒滤波可以匹配更复杂的矩阵滤波器的性能。通过协调RF和多普勒滤波器的选择，而不是顺序设计这些滤波器，可以使试剂与组织的对比度提高3.9 dB。在某些情况下，对于间歇性多普勒成像，基本的RF滤波性能优于谐波滤波。

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