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首页> 外文期刊>International Journal of Hygiene and Environmental Health >Quality assurance and harmonization for targeted biomonitoring measurements of environmental organic chemicals across the Children's Health Exposure Analysis Resource laboratory network
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Quality assurance and harmonization for targeted biomonitoring measurements of environmental organic chemicals across the Children's Health Exposure Analysis Resource laboratory network

机译：儿童健康曝光分析资源实验网络环境有机化学型环境有机化学品有针对性生物监唱测量的质量保证及协调

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A consortium of laboratories established under the Children?s Health Exposure Analysis Resource (CHEAR) used a multifaceted quality assurance program to promote measurement harmonization for trace organics analyses of human biospecimens that included: (1) participation in external quality assurance (EQA)/proficiency testing (PT) programs; (2) analyses of a urine-based CHEAR common quality control (QC) pool with each analytical batch across all participating laboratories; (3) method validation against NIST Standard Reference Materials? (SRMs); and (4) analyses of blinded duplicates and other project-specific QC samples. The capability of five CHEAR laboratories in organic chemical analysis increased across the 4-year period, and performance in the external PT program improved over time ? recent challenges reporting 90% analytes with satisfactory performance. The CHEAR QC pools were analyzed for several classes of organic chemicals including phthalate metabolites and environmental phenols by the participating laboratories with every batch of project samples, which provided a rich source of measurement data for the assessment of intra- and inter-laboratory variance. Within-laboratory and overall variabilities in measurements across laboratories were calculated for target chemicals in urine QC pools; the coefficient of variation (CV) was generally below 25% across batches, studies and laboratories and indicated acceptable analytical imprecision. The suite of organic chemicals analyzed in the CHEAR QC pool was broader than those reported for commercially available reference materials. The accuracy of each of the laboratories? methods was verified through the analysis of several NIST SRMs and was, for example, 97 ? 5.2% for environmental phenols and 95 ? 11% for phthalates. Analysis of blinded duplicate samples showed excellent agreement and reliability of measurements. The intra-class correlation coefficients (ICC) for phthalate metabolites analyzed in various batches across three CHEAR laboratories showed excellent reliability (typically 0.90). Overall, the multifaceted quality assurance protocols followed among the CHEAR laboratories ensured reliable and reproducible data quality for several classes of organic chemicals. Increased participation in external PT programs through inclusion of additional target analytes will further enhance the confidence in data quality.
机译：在儿童的健康曝光分析资源（Chear）下建立的实验室联盟使用多方面的质量保证计划，以促进痕量有机体分析的测量协调，包括：（1）参与外部质量保证（EQA）/熟练程度测试（PT）计划; （2）分析基于尿基Chear常见质量控制（QC）池，每个参与实验室的每个分析批次; （3）对NIST标准参考资料的方法验证？ （SRMS）; （4）分析盲化复制品和其他项目特异性QC样本。在4年期间有机化学分析中的五个Chear实验室的能力在4年期间增加，外部PT程序中的性能随着时间的推移而得到改善？最近的挑战报告＆ 90％的分析物，具有令人满意的性能。分析了QC池的几种有机化学物质，包括邻苯二甲酸酯代谢物和环境酚，并通过每批项目样本，为评估和实验室间差异提供丰富的测量数据来源。实验室内的实验室和整体变量在尿QC池中的靶化学品计算了实验室的测量中的综合变量;批量，研究和实验室的变异系数通常低于25％，并表明了可接受的分析不精确。在Chear QC池中分析的有机化学品套装比商业上可获得的参考资料的分析更宽。每个实验室的准确性？通过分析几个NIST SRMS验证了方法，例如，97？环境酚和95的5.2％？邻苯二甲酸盐11％。盲化重复样本的分析显示出优异的一致性和测量可靠性。在三种Chear实验室中分析各种批次分析的邻苯二甲酸酯代谢物的类相关系数（ICC）表现出优异的可靠性（通常是＆ 0.90）。总的来说，Chear实验室中的多方面质量保证协议确保了几种课堂有机化学品的可靠和可重复的数据质量。通过包含额外的目标分析来增加外部PT程序的参与将进一步增强对数据质量的置信度。

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