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首页> 外文期刊>Journal of Infectious Diseases >Macrophage Impairment Underlies Airway Occlusion in Primary Respiratory Syncytial Virus Bronchiolitis
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Macrophage Impairment Underlies Airway Occlusion in Primary Respiratory Syncytial Virus Bronchiolitis

机译：巨噬细胞受损是原发性呼吸道合胞病毒细支气管炎的气道阻塞的基础

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摘要

Although respiratory syncytial virus (RSV) infection is the most important cause of bronchiolitis in infants, the pathogenesis of RSV disease is poorly described. We studied histopathologic changes in a panel of lung tissue specimens obtained from infants with fatal cases of primary RSV infection. In these tissues, airway occlusion with accumulations of infected, apoptotic cellular debris and serum protein was consistently observed. Similar observations were found after RSV infection in New Zealand black (NZB) mice, which have constitutive deficiencies in macrophage function, but not in BALB/c mice. A deficiency in the number of alveolar macrophages in NZB mice appears to be central to enhanced disease, because depletion of alveolar macrophages in BALB/c mice before RSV exposure resulted in airway occlusion. In mice with insufficient numbers of macrophages, RSV infection yielded an increased viral load and enhanced expression of type I interferon-associated genes at the height of disease. Together, our data suggest that innate, rather than adaptive, immune responses are critical determinants of the severity of RSV bronchiolitis.
机译：尽管呼吸道合胞病毒（RSV）感染是婴儿毛细支气管炎的最重要原因，但对RSV疾病的发病机理的描述却很少。我们研究了从患有原发性RSV感染致命病例的婴儿获得的一组肺组织标本中的组织病理学变化。在这些组织中，始终观察到气道阻塞伴有感染性凋亡细胞碎片和血清蛋白的积累。在RSV感染后，在新西兰黑（NZB）小鼠中发现了类似的观察结果，这些小鼠在巨噬细胞功能上具有组成性缺陷，而在BALB / c小鼠中则没有。 NZB小鼠中肺泡巨噬细胞数量的缺乏似乎是疾病增强的关键，因为在暴露于RSV之前，BALB / c小鼠的肺泡巨噬细胞耗竭导致气道阻塞。在巨噬细胞数量不足的小鼠中，RSV感染会在疾病高峰期增加病毒载量并增强I型干扰素相关基因的表达。总之，我们的数据表明，先天性而非适应性免疫反应是RSV细支气管炎严重程度的关键决定因素。

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