On a variance stabilizing model and its application to genomic data

Filidor Vilca; Mariana Rodrigues-Motta; Victor Leiva

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On a variance stabilizing model and its application to genomic data

机译：方差稳定模型及其在基因组数据中的应用

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摘要

In this paper, we propose a model based on a class of symmetric distributions, which avoids the transformation of data, stabilizes the variance of the observations, and provides robust estimation of parameters and high flexibility for modeling different types of data. Probabilistic and statistical aspects of this new model are developed throughout the article, which include mathematical properties, estimation of parameters and inference. The obtained results are illustrated by means of real genomic data.

机译：在本文中，我们提出了一种基于一类对称分布的模型，该模型避免了数据的转换，稳定了观测值的方差，并提供了可靠的参数估计和为不同类型的数据建模提供的高度灵活性。在整个文章中，都会开发此新模型的概率和统计方面，包括数学属性，参数估计和推论。所得结果通过真实的基因组数据进行说明。

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来源
《Journal of applied statistics》 |2013年第12期|2354-2371|共18页
作者
Filidor Vilca; Mariana Rodrigues-Motta; Victor Leiva;
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作者单位

Departamento de Estatistica, Universidade Estadual de Campinas, Sao Paulo, Brazil;

Departamento de Estatistica, Universidade Estadual de Campinas, Sao Paulo, Brazil;

Departamento de Estadistica, Universidad de Valparaiso, Valparaiso, Chile;

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正文语种 eng
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关键词
EM algorithm; Johnson system distributions; maximum-likelihood method; non-normality; normal scale mixture distributions; transformations;

机译：EM算法;约翰逊系统分布;最大似然法非正常正常比例的混合物分布;转变;

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1. CART variance stabilization and regularization for high-throughput genomic data [J] . Papana A, Ishwaran H Bioinformatics . 2006,第18期

机译：高通量基因组数据的CART方差稳定和正则化
2. CART variance stabilization and regularization for high-throughput genomic data [J] . Papana A, Ishwaran H Bioinformatics . 2006,第18期

机译：高通量基因组数据的CART方差稳定和正则化
3. CART variance stabilization and regularization for high-throughput genomic data [J] . Ariadni Papana, and Hemant Ishwaran Bioinformatics . 2006,第18期

机译：高通量基因组数据的CART方差稳定和正则化
4. VARIANCE STABILIZATION OF NONCENTRAL-CHI DATA: APPLICATION TO NOISE ESTIMATION IN MRI [C] . Tomasz Pieciak, Gonzalo Vegas-Sanchez-Ferrero, Santiago Aja-Fernandez IEEE International Symposium on Biomedical Imaging . 2016

机译：无共和克数据的方差稳定：MRI中的噪声估计
5. Neighbor relation modeling and variance component identification in hierarchical areal data models with application to periodontology, cancer epidemiology, and sports. [D] . Reich, Brian James. 2005

机译：分层区域数据模型中的邻居关系建模和方差成分识别，并应用于牙周病学，癌症流行病学和体育运动。
6. Improving Hierarchical Models Using Historical Data with Applications in High-Throughput Genomics Data Analysis [O] . Ben Li, Yunxiao Li, Zhaohui S. Qin -1

机译：使用历史数据改进分层模型及其在高通量基因组学数据分析中的应用
7. CART variance stabilization and regularization for high-throughput genomic data [O] . A. Papana, H. Ishwaran 2006

机译：高吞吐量基因组数据的购物车方差稳定和正则化

On a variance stabilizing model and its application to genomic data

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