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A Pilot Randomized Controlled Trial of Omega-3 Fatty Acids for Autism Spectrum Disorder

机译:Omega-3脂肪酸对自闭症谱系障碍的随机对照试验

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We conducted a pilot randomized controlled trial to determine the feasibility and initial safety and efficacy of omega-3 fatty acids (1.3 g/day) for the treatment of hyperactivity in 27 children ages 3–8 with autism spectrum disorder (ASD). After 12 weeks, hyperactivity, as measured by the Aberrant Behavior Checklist, improved 2.7 (±4.8) points in the omega-3 group compared to 0.3 (±7.2) points in the placebo group (p = 0.40; effect size = 0.38). Correlations were found between decreases in five fatty acid levels and decreases in hyperactivity, and the treatment was well tolerated. Although this pilot study did not find a statistically significant benefit from omega-3 fatty acids, the small sample size does not rule out small to moderate beneficial effects.
机译:我们进行了一项先导性随机对照试验,以确定omega-3脂肪酸(1.3克/天)用于治疗27例3-8岁自闭症谱系障碍(ASD)多动症的可行性,初始安全性和有效性。 12周后,异常行为检查表测得的活动过度改善了omega-3组的2.7(±4.8)点,而安慰剂组为0.3(±7.2)点(p = 0.40;效应量= 0.38)。发现在五种脂肪酸水平降低与多动性降低之间存在相关性,并且治疗耐受性良好。尽管该初步研究未发现omega-3脂肪酸具有统计学上的显着益处,但小样本量并不能排除小到中度的有益作用。

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