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Finnish Prenatal Study of Autism and Autism Spectrum Disorders (FIPS-A): Overview and Design

机译:芬兰自闭症和自闭症谱系疾病的产前研究(FIPS-A):概述和设计

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This article presents an overview of the Finnish Prenatal Study of Autism and Autism Spectrum Disorders (FIPS-A), a new study designed to examine the relationship between prenatal serologic factors, mediating and moderating developmental antecedents, and risk of autism spectrum disorders (ASD). The FIPS-A is based on register linkages between births from 1987 to 2005 ascertained from the Finnish Medical Birth Register (FMBR) and other national registers on treatment for this group of disorders. All subjects were members of the Finnish Maternity Cohort (FMC), which consists of virtually all births in Finland from 1983 to the present, and which includes archived maternal serum samples. This study also capitalizes on other registry information, such as systematically collected data on pregnancy, prenatal and neonatal complications and manual data collection from well-child clinics providing developmental data from birth to the age of 7 years. In this paper, we describe the methods used in the FIPS-A study, including a description of the national registers, available data and case ascertainment procedures. Finally, we discuss implications of the data for future work on uncovering putative aetiologies of ASD and key strengths and limitations of the design.
机译:本文介绍了芬兰自闭症和自闭症谱系疾病产前研究(FIPS-A)的概述,该研究旨在检查产前血清学因素,介导和调节发育前因与自闭症谱系障碍(ASD)风险之间的关系。 FIPS-A是基于1987年至2005年之间的出生登记联系而确定的,该联系是从芬兰医疗出生登记簿(FMBR)和其他有关此类疾病的治疗的国家登记簿确定的。所有受试者均为芬兰产妇队列(FMC)的成员,该组实际上包括1983年至今芬兰的所有出生,并包括存档的孕妇血清样本。这项研究还利用了其他注册表信息,例如系统地收集了有关怀孕,产前和新生儿并发症的数据,以及从良好的儿童诊所收集的人工数据,这些数据提供了从出生到7岁的发育数据。在本文中,我们描述了FIPS-A研究中使用的方法,包括对国家注册簿的描述,可用数据和案例确定程序。最后,我们讨论了数据在发现ASD的病因以及设计的主要优点和局限性方面对未来工作的影响。

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