Brief Report: “Allergic Symptoms” in Children with Autism Spectrum Disorders. More than Meets the Eye?

Asimenia Angelidou; Konstantinos-Dionysios Alysandratos; Shahrzad Asadi; Bodi Zhang; Konstantinos Francis; Magdalini Vasiadi; Dimitrios Kalogeromitros; Theoharis C. Theoharides

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Brief Report: “Allergic Symptoms” in Children with Autism Spectrum Disorders. More than Meets the Eye?

机译：简要报告：自闭症谱系障碍儿童的“过敏症状”。不只是对视？

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Many children with Autism Spectrum Disorders (ASD) have either family and/or personal history of “allergic symptomatology”, often in the absence of positive skin or RAST tests. These symptoms may suggest mast cell activation by non-allergic triggers. Moreover, children with mastocytosis or mast cell activation syndrome (MCAS), a spectrum of rare diseases characterized by increased number of activated mast cells in many organs, appear to have ASD at a rate tenfold higher (1/10 children) than that of the general population (1/100 children). Mast cell activation by allergic, infectious, environmental and stress-related triggers, especially perinatally, would release pro-inflammatory and neurotoxic molecules. We speculate these could disrupt the gut–blood–brain barriers, thus contributing to brain inflammation and ASD pathogenesis. Increased mast cell responsiveness may define at least a subgroup of ASD subjects, who could benefit from inhibition of mast cell activation.

机译：许多患有自闭症谱系障碍（ASD）的儿童经常有家族和/或个人的“过敏性症状学”病史，通常没有阳性皮肤或RAST测试。这些症状可能表明肥大细胞是由非过敏性诱因激活的。此外，患有肥大细胞增多症或肥大细胞活化综合症（MCAS）的儿童（其特征是许多器官中激活的肥大细胞数量增加）的罕见疾病谱系，其ASD的发生率（儿童的1/10）比儿童的高十倍。普通人群（1/100名儿童）。肥大细胞通过变态反应，传染性，环境和应激相关的触发而激活，特别是在围产期，会释放促炎和神经毒性分子。我们推测这些可能破坏肠-血-脑屏障，从而促进脑部炎症和ASD发病机理。肥大细胞反应性增强可能会定义至少一个ASD受试者亚组，这些受试者可以受益于抑制肥大细胞活化。

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来源
《Journal of Autism and Developmental Disorders》 |2011年第11期|p.1579-1585|共7页
作者
Asimenia Angelidou; Konstantinos-Dionysios Alysandratos; Shahrzad Asadi; Bodi Zhang; Konstantinos Francis; Magdalini Vasiadi; Dimitrios Kalogeromitros; Theoharis C. Theoharides;
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作者单位

Molecular Immunopharmacology and Drug Discovery Laboratory, Department of Molecular Physiology and Pharmacology, Tufts University School of Medicine, Suite M&ampV-208, 136 Harrison Avenue, Boston, MA, 02111, USA;

Molecular Immunopharmacology and Drug Discovery Laboratory, Department of Molecular Physiology and Pharmacology, Tufts University School of Medicine, Suite M&ampV-208, 136 Harrison Avenue, Boston, MA, 02111, USA;

Molecular Immunopharmacology and Drug Discovery Laboratory, Department of Molecular Physiology and Pharmacology, Tufts University School of Medicine, Suite M&ampV-208, 136 Harrison Avenue, Boston, MA, 02111, USA;

Molecular Immunopharmacology and Drug Discovery Laboratory, Department of Molecular Physiology and Pharmacology, Tufts University School of Medicine, Suite M&ampV-208, 136 Harrison Avenue, Boston, MA, 02111, USA;

Child Psychiatry Section, Second Dep;

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正文语种 eng
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关键词
Allergy; Autism; Brain; Food intolerance; Inflammation; Mast cells;

机译：过敏;自闭症;脑;食物不耐受;炎症;肥大细胞;

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Brief Report: “Allergic Symptoms” in Children with Autism Spectrum Disorders. More than Meets the Eye?

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