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Is Neonatal Jaundice Associated with Autism Spectrum Disorders: A Systematic Review

机译：是新生儿黄疸与自闭症谱系障碍：系统的审查

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摘要

Using guidelines of the Meta-analysis of Observational Studies in Epidemiology Group, we systematically reviewed the literature on neonatal jaundice (unconjugated hyperbilirubinemia) and Autism Spectrum Disorder (ASD) in term and preterm infants. Thirteen studies were included in a meta-analysis. Most used retrospective matched case–control designs. There was significant heterogeneity (Q = 31, p = 0.002) and no evidence of publication bias (p = 0.12). Overall, jaundice, assessed by total serum bilirubin (TSB), was associated with ASD (OR, 1.43, 95% CI 1.22–1.67, random effect model). This association was not found in preterms (OR 0.7, 95% CI 0.38–1.02) but deserves further investigation since other measures of bilirubin such as unbound unconjugated bilirubin may be better predictors of neurotoxicity than TSB in preterms.
机译：根据流行病学组观察性研究的荟萃分析指南，我们系统地回顾了足月和早产儿新生儿黄疸（非共轭高胆红素血症）和自闭症谱系障碍（ASD）的文献。荟萃分析包括十三项研究。最常用的回顾性匹配病例对照设计。有显着的异质性（Q = 31，p = 0.002），没有证据表明存在出版偏倚（p = 0.12）。总体而言，黄疸是通过总血清胆红素（TSB）评估的，与ASD相关（OR，1.43，95％CI 1.22-1.67，随机效应模型）。在早产中未发现这种关联（OR 0.7，95％CI 0.38–1.02），但值得进一步研究，因为在早产中，其他措施的胆红素（如未结合的未结合胆红素）可能比TSB更好地预测神经毒性。

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