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Network Model of Decreased Context Utilization in Autism Spectrum Disorder

机译:自闭症谱系障碍的语境利用减少网络模型

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摘要

Individuals with autism spectrum disorders (ASD) demonstrate impaired utilization of context, which allows for superior performance on the “false memory” task. We report the application of a simplified parallel distributed processing model of context utilization to the false memory task. For individuals without ASD, experiments support a model wherein presentation of one word, e.g., ‘‘apple,’’ strongly activates the neighboring nodes of closely related words such as ‘‘fruit,’’ ‘‘tree,’’ whereas in ASD these neighboring nodes are relatively less activated. We demonstrate this model to be consistent with the superior performance on recognition testing on the false memory test, but not on free recall. This may have an anatomic basis in diminished hippocampal neuronal arborization and the abnormal minicolumnar pathology in ASD.
机译:患有自闭症谱系障碍(ASD)的人表现出对上下文的利用受损,从而在“错误记忆”任务上表现出出色的表现。我们报告了上下文利用的简化的并行分布式处理模型在错误的内存任务中的应用。对于没有ASD的个人,实验支持一种模型,其中出现一个单词(例如“苹果”)会强烈激活紧密相关的单词(例如“水果”,“树”)的相邻节点,而在ASD中,相邻节点的激活相对较少。我们证明此模型与在错误记忆测试中进行识别测试时的优异性能一致,但在免费召回中却没有。这可能在减少海马神经元乔化和ASD的小柱状病理异常方面具有解剖学基础。

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