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Expressive language abilities of boys with idiopathic autism spectrum disorder and boys with fragile X syndrome + autism spectrum disorder: Cross-context comparisons

机译:具有特发性自闭症谱系疾病的男性的表达语言能力和脆弱X综合征+自闭症谱系:跨情谱比较

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摘要

Background and aims Understanding the unique expressive language profiles of children with phenotypically similar, but distinct neurodevelopmental disorders, such as idiopathic autism spectrum disorder and fragile X syndrome with a co-diagnosis of autism spectrum disorder (fragile X syndrome + autism spectrum disorder), has both clinical and theoretical implications. However, comparative studies of these two clinical groups have been limited, and results have been inconsistent, partially as a result of different assessment methods being utilized. Thus, the current study compared the expressive language profiles of boys with idiopathic autism spectrum disorder and boys with fragile X syndrome + autism spectrum disorder and examined whether a similar linguistic profile emerged across different language sampling contexts: a semi-structured conversation and the Autism Diagnostic Observation Schedule. Methods Eighteen boys with autism spectrum disorder ( M age  = 13.25 years) and 19 boys with fragile X syndrome + autism spectrum disorder ( M age  = 12.19 years), matched on autism spectrum disorder symptom severity and similar in terms of chronological age and mean length of utterance, participated in this study. Boys produced two language samples: one semi-structured conversation and one taken from the Autism Diagnostic Observation Schedule. Language samples were coded for talkativeness, lexical diversity, mean length of utterance, intelligibility, and repetitive or perseverative language. Results Analyses revealed that boys with autism spectrum disorder produced language samples that were more lexically diverse and intelligible, and that included less topic perseveration compared to boys with fragile X syndrome + autism spectrum disorder. With regards to sampling context, boys in both groups were more talkative and produced longer and more intelligible utterances in their conversation sample compared to their Autism Diagnostic Observation Schedule sample. However, boys with autism spectrum disorder and fragile X syndrome + autism spectrum disorder used a higher proportion of topic perseveration during the conversation sample. Conclusions Overall, we found similarities as well as distinctions in the expressive language profiles of boys with fragile X syndrome + autism spectrum disorder and boys with idiopathic autism spectrum disorder. Moreover, the Autism Diagnostic Observation Schedule sample elicited a relatively different language profile than the conversation sample for boys in both groups. Implications These findings help to further elucidate the unique language phenotypes of boys with idiopathic autism spectrum disorder and boys with fragile X syndrome + autism spectrum disorder. Moreover, our findings indicate that multiple language samples may be needed to obtain a comprehensive account of a child’s expressive language ability.
机译:背景和旨在了解具有表现形式的儿童的独特表达语言概况,但不同的神经发育障碍,如特发性自闭症谱系障碍和脆弱的X综合征,具有共同主义谱系障碍(易血症X综合征+自闭症谱系),具有临床和理论意义。然而,对这两种临床基团的比较研究受到限制,并且由于使用的不同评估方法,部分是不一致的。因此,目前的研究比较了具有特发性自闭症谱系障碍和具有脆弱X综合征+自闭症谱系疾病的男孩的表现力语言概况,并检查了不同语言采样背景中出现的类似语言学的形象:半结构化对话和自闭症诊断观察时间表。方法患有自闭症谱系障碍(龄= 13.25岁)的十八名男孩,19名男孩脆弱X综合征+自闭症谱系(米龄= 12.19岁),符合自闭症谱系症状严重程度,在年龄年龄和平均长度方面相似话语,参加了这项研究。男孩制作了两种语言样本:一个半结构化的谈话和一项从自闭症诊断观察时间表中取得的一个。语言样本被编码,用于谈论,词汇分集,话语,可懂度和重复或坚持性语言的平均长度。结果分析显示,与具有脆弱X综合征+自闭症+自闭症谱系+自闭症频谱+自闭症谱系+自闭症+自闭症频谱+自闭症频谱+自闭症谱系+自闭症频谱+自闭症频谱+自闭症+自闭症频谱+自闭症+自闭症+自闭症+自闭症+自闭症谱系+自闭症+自闭症+自闭症+自闭症谱紊乱的男孩的语言样本产生的语言样本。关于采样背景,与自闭症诊断观察调度样本相比,两组中的男孩在他们的谈话样本中更加健美,并且在他们的谈话样本中产生了更长,更聪明的话语。然而,具有自闭症谱系疾病和脆弱X综合征+自闭症谱系疾病的男孩在对话样本期间使用了更高比例的主题持久性。结论:总体而言,我们的相似之处,以及区别在男孩脆性X综合征+自闭症谱系障碍和男孩特发性自闭症谱系障碍的语言表达谱。此外,自闭症诊断观察计划样本引发了比两组男孩的对话样本相对不同的语言曲线。含义这些发现有助于进一步阐明具有特发性自闭症谱系和具有脆弱X综合征+自闭症谱系疾病的男孩的独特语言表型。此外,我们的研究结果表明,可能需要多种语言样本来获得儿童表达语言能力的全面叙述。

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