Relevance of Donepezil in Enhancing Learning and Memory in Special Populations: A Review of the Literature

J. Helen Yoo; Maria G. Valdovinos; Dean C. Williams

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Relevance of Donepezil in Enhancing Learning and Memory in Special Populations: A Review of the Literature

机译：多奈哌齐对增强特殊人群的学习和记忆的相关性：文献综述

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摘要

This review discusses the laboratory and clinical research supporting the rationale for the efficacy of donepezil (Aricept? USA) in enhancing cognition in autism, Alzheimer disease, Down syndrome, traumatic brain injury, Attention Deficit Hyperactivity Disorder (ADHD), and schizophrenia. While preliminary animal models have shown effective, human studies exclusive of Alzheimer disease are sparse. Although attention and memory are unlikely a sole operation of the cholinergic system, evidence indicates a promising direction for further examination of this hypothesis in autism. Studies that examine changes in operationally defined behaviors and reliable and valid measure of changes in attention and memory are needed.

机译：这篇综述讨论了支持多奈哌齐（Aricept？USA）增强自闭症，阿尔茨海默氏病，唐氏综合症，颅脑外伤，注意力缺陷多动障碍（ADHD）和精神分裂症认知能力的基本原理的实验室和临床研究。初步的动物模型显示有效，但除阿尔茨海默氏病以外的人类研究稀疏。尽管注意力和记忆力不太可能是胆碱能系统的唯一操作，但证据表明进一步检查自闭症假说的前景广阔。需要研究检查操作定义的行为的变化以及注意力和记忆力变化的可靠有效方法。

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来源
《Journal of Autism and Developmental Disorders》 |2007年第10期|1883-1901|共19页
作者
J. Helen Yoo; Maria G. Valdovinos; Dean C. Williams;
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作者单位

Center for Autism and Related Disorders 3001 Bee Caves Road Austin TX 78746 USA;

Psychology Department Drake University 2507 University Avenue Des Moines IA 50311 USA;

Parsons Research Center University of Kansas 2601 Gabriel Parsons KS 67357 USA;

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正文语种 eng
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关键词
Autism; Donepezil (Aricept); Acetylcholine;

机译：自闭症;多奈哌齐（Aricept）;乙酰胆碱;

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1. Donepezil plus estradiol treatment enhances learning and delay-dependent memory performance by young ovariectomized rats with partial loss of septal cholinergic neurons. [J] . Gibbs RB, Chipman AM, Nelson D Hormones and behavior . 2011,第4期

机译：多奈哌齐联合雌二醇治疗可增强卵巢切除的年轻大鼠的学习能力，并使其具有延迟依赖性的记忆功能，但部分间隔的胆碱能神经元会丢失。
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6. Donepezil Plus Estradiol Treatment Enhances Learning and Delay-Dependent Memory Performance by Young Ovariectomized Rats with Partial Loss of Septal Cholinergic Neurons [O] . R.B. Gibbs, A.M. Chipman, D. Nelson -1

机译：Donepezil Plus雌二醇治疗通过幼卵细胞切除大鼠进行部分丧失的儿童胆碱能神经元的学习和延迟依赖记忆性能
7. Donepezil plus estradiol treatment enhances learning and delay-dependent memory performance by young ovariectomized rats with partial loss of septal cholinergic neurons [O] . R.B. Gibbs, A.M. Chipman, D. Nelson 2011

机译：Donepezil Plus雌二醇治疗通过幼卵细胞切除大鼠进行部分丧失的儿童胆碱能神经元的学习和延迟依赖记忆性能
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Relevance of Donepezil in Enhancing Learning and Memory in Special Populations: A Review of the Literature

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