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首页> 外文期刊>Journal of Autism and Developmental Disorders >Individuals with Autism Spectrum Disorder Show Normal Responses to a Fear Potential Startle Paradigm
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Individuals with Autism Spectrum Disorder Show Normal Responses to a Fear Potential Startle Paradigm

机译：自闭症谱系障碍患者对恐惧潜在的惊吓范例表现出正常反应

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The present study utilized a fear potentiated startle paradigm to examine amygdala function in individuals with autism spectrum disorder. Two competing hypotheses regarding amygdala dysfunction in autism have been proposed: (1) The amygdala is under-responsive, in which case it would be predicted that, in a fear potentiated startle experiment, individuals with autism would exhibit decreased fear conditioning and/or potentiation, and (2) The amygdala is over responsive, in which case an exaggerated potentiation of the startle response would be predicted. Fourteen adolescents and adults diagnosed with autism spectrum disorder and 14 age, gender, IQ, and anxiety level-matched typical adolescents and adults participated. Both participants with autism and typical participants potentiated the startle response following fear conditioning and no group differences in the latency or amplitude of the potentiated startle response were found. These results suggest that this aspect of amygdala function, namely fear conditioning and potentiation of the startle response, is intact in individuals with autism.
机译：本研究利用恐惧增强的惊吓范例检查自闭症谱系障碍患者的杏仁核功能。关于自闭症的杏仁核功能障碍，提出了两个相互竞争的假设：（1）杏仁核反应不足，在这种情况下，可以预见，在恐惧增强的惊吓实验中，自闭症患者的恐惧条件和/或增强能力会降低（2）杏仁核反应过度，在这种情况下，可以预料到惊吓反应的增强作用。十四名青少年和成年人被诊断出患有自闭症谱系障碍，年龄，性别，智商和焦虑水平相匹配的十四名青少年和成年人参加了研究。自闭症参与者和典型参与者在恐惧调节后均增强了惊恐反应，未发现增强的惊恐反应的潜伏期或振幅存在群体差异。这些结果表明杏仁核功能的这一方面，即恐惧条件和惊吓反应的增强，在自闭症患者中是完整的。

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