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首页> 外文期刊>Journal of Autism and Developmental Disorders >Lateralization in Individuals with High-Functioning Autism and Asperger's Disorder: A Frontostriatal Model
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Lateralization in Individuals with High-Functioning Autism and Asperger's Disorder: A Frontostriatal Model

机译：高功能自闭症和阿斯伯格症患者的横向化：额骨模型

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Neurobiological and behavioural studies of possible left hemisphere dysfunction in autism have generated conflicting results. Left hemisphere dysfunction may manifest in autism only in tasks that invoke executive functions. Moreover, left hemisphere dysfunction may underpin autism but not Asperger's disorder. We thus aimed to systematically investigate reports of anomalous lateralization in individuals with high-functioning autism and Asperger's disorder. Two of the tasks were sensitive to executive dysfunction: a serial choice reaction-time task and a Posner-type paradigm; the remaining tasks instead investigated aspects of perceptual lateralisation. Compared with age- and IQ-matched controls, the autism group displayed deficiencies in right hemispace (and by implication, left hemisphere) performance on both executive function tasks; however, this group demonstrated normal lateralization effects on the nonexecutive, visual-perceptual tasks. In contrast, the Asperger's disorder group showed similar laterality effects to their age- and IQ-matched controls on both executive and nonexecutive function tasks. The etiological relevance of this neurobehavioral dissociation between high-functioning autism and Asperger's disorder was discussed; in particular, it was suggested that the period where dominance shifts from right to left hemisphere is important in whatever process might dictate the emergence of either autism or Asperger's disorder.
机译：自闭症中可能存在的左半球功能障碍的神经生物学和行为学研究产生了矛盾的结果。左半球功能障碍仅在调用执行功能的任务中可能表现为自闭症。此外，左半球功能障碍可能是自闭症的基础，而不是阿斯伯格综合症的基础。因此，我们旨在系统研究具有高功能自闭症和阿斯伯格症的人的异常侧偏的报告。其中两项任务对执行功能障碍敏感：串行选择反应时间任务和Posner型范例；其余的任务取而代之的是研究知觉偏侧化的方面。与年龄和智商相匹配的对照组相比，自闭症组在两项执行功能任务中均表现出右半空间（并暗示左半球）的表现不足；然而，该组对非执行性视觉感知任务表现出正常的偏侧作用。相比之下，阿斯伯格氏症组在执行和非执行功能任务上表现出与年龄和智商相称的对照相似的偏侧效应。讨论了高功能自闭症和阿斯伯格疾病之间这种神经行为分离的病因学相关性。尤其是，有人建议，在可能决定自闭症或阿斯伯格疾病出现的任何过程中，主导权从右半球转移到左半球的时期都很重要。

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