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Combination of a MDR1-targeted replicative adenovirus and chemotherapy for the therapy of pretreated ovarian cancer

机译:靶向MDR1的复制型腺病毒与化学疗法联合治疗卵巢癌

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摘要

Targeted oncolytic adenoviruses capable of replication selectively in cancer cells are an appealing approach for the treatment of various cancer types refractory to conventional therapies. The aim of this study was to evaluate the effect of Ad5/3MDR1E1, a multidrug resistance gene 1 (MDR1)-targeted fiber-modified replication-competent adenovirus for the therapy of platinum-pretreated ovarian cancer in combination with cytostatic agents.
机译:能够在癌细胞中选择性复制的靶向溶瘤腺病毒是治疗常规疗法难治的各种癌症的诱人方法。这项研究的目的是评估Ad5 / 3MDR1E1(一种靶向多药耐药基因1(MDR1)的纤维修饰的具有复制能力的腺病毒)对铂预处理的卵巢癌与细胞抑制剂联合治疗的效果。

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