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首页> 外文期刊>Journal of Chemical Crystallography >Synthesis, Crystal Structure and DNA-Binding Properties of a Zinc(II) Complex with 1,3-Bis(1-propylbenzimidazol-2-yl)-2-oxapropane
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Synthesis, Crystal Structure and DNA-Binding Properties of a Zinc(II) Complex with 1,3-Bis(1-propylbenzimidazol-2-yl)-2-oxapropane

机译：1,3-双（1-丙基苯并咪唑-2-基）-2-氧丙烷的锌（II）配合物的合成，晶体结构和DNA结合特性

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摘要

A complex of formula [Zn(pobb)2]·2pic, (pobb = 1,3-bis(1-propylbenzimidazol-2-yl)-2-oxapropane, pic = 2,4,6-trinitrophenol), has been synthesized and structurally characterized by elemental analysis, IR, UV–Vis spectral measurements. The crystals crystallize in the monoclinic system, space group C2/c, a = 25.77(2) Å, b = 15.227(13) Å, c = 19.281(17) Å, α = 90°, β = 129.544(7)°, γ = 90°, Z = 4. The coordination environment around zinc(II) atom can be described as a distorted octahedral geometry. The interactions of the ligand pobb and the zinc(II) complex with calf thymus DNA (CT-DNA) are investigated by using electronic absorption titration, ethidium bromide-DNA displacement experiments and viscosity measurements. The experimental evidence indicated the pobb and the zinc(II) complex interact with CT-DNA through intercalation.
机译：式[Zn（pobb）2 ]·2pic的配合物，（pobb = 1,3-双（1-丙基苯并咪唑-2-基）-2-氧丙烷，pic = 2,4,6-三硝基苯酚）已通过元素分析，IR，UV-Vis光谱测量进行了合成并在结构上进行了表征。晶体在单斜晶系C2 / c空间群中结晶，a = 25.77（2）Å，b = 15.227（13）Å，c = 19.281（17）Å，α= 90°，β= 129.544（7）° ，γ= 90°，Z =4。围绕锌（II）原子的配位环境可以描述为扭曲的八面体几何形状。通过电子吸收滴定，溴化乙锭-DNA置换实验和粘度测量研究了配体pobb和锌（II）与小牛胸腺DNA（CT-DNA）的相互作用。实验证据表明，pobb和锌（II）配合物通过嵌入与CT-DNA相互作用。

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  • 来源
    《Journal of Chemical Crystallography》 |2012年第8期|p.884-890|共7页
  • 作者

    Huilu Wu; Fan Kou; Fei Jia; Bin Liu; Jingkun Yuan; Ying Bai;

  • 作者单位

    School of Chemical and Biological Engineering, Lanzhou Jiaotong University, Lanzhou, 730070, Gansu, People’s Republic of China;

    School of Chemical and Biological Engineering, Lanzhou Jiaotong University, Lanzhou, 730070, Gansu, People’s Republic of China;

    School of Chemical and Biological Engineering, Lanzhou Jiaotong University, Lanzhou, 730070, Gansu, People’s Republic of China;

    School of Chemical and Biological Engineering, Lanzhou Jiaotong University, Lanzhou, 730070, Gansu, People’s Republic of China;

    School of Chemical and Biological Engineering, Lanzhou Jiaotong University, Lanzhou, 730070, Gansu, People’s Republic of China;

    School of Chemical and Biological Engineering, Lanzhou Jiaotong University, Lanzhou, 730070, Gansu, People’s Republic of China;

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  • 正文语种 eng
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  • 关键词

    1,3-Bis(1-propylbenzimidazol-2-yl)-2-oxopropane; Zinc(II) complex; Crystal structure; DNA binding property;

    机译：1,3-双（1-丙基苯并咪唑-2-基）-2-氧丙烷;锌（II）配合物;晶体结构;DNA结合特性;

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