...
  • 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>Journal of Cognitive Neuroscience >White Matter Changes Compromise Prefrontal Cortex Function in Healthy Elderly Individuals
【24h】

White Matter Changes Compromise Prefrontal Cortex Function in Healthy Elderly Individuals

机译：白色物质的变化损害了健康老年人的前额叶皮层功能

获取原文
获取原文并翻译 | 示例
           
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

Changes in memory function in elderly individuals are often attributed to dysfunction of the prefrontal cortex (PFC). One mechanism for this dysfunction may be disruption of white matter tracts that connect the PFC with its anatomical targets. Here, we tested the hypothesis that white matter degeneration is associated with reduced prefrontal activation. We used white matter hyperintensities (WMH), a magnetic resonance imaging (MRI) finding associated with cerebrovascular disease in elderly individuals, as a marker for white matter degeneration. Specifically, we used structural MM to quantify the extent of WMH in a group of cognitively normal elderly individuals and tested whether these measures were predictive of the magnitude of prefrontal activity (fMRI) observed during performance of an episodic retrieval task and a verbal working memory task. We also examined the effects of WMH located in the dorsolat-eral frontal regions with the hypothesis that dorsal PFC WMH would be strongly associated with not only PFC function, but also with areas that are anatomically and functionally linked to the PFC in a task-dependent manner. Results showed that increases in both global and regional dorsal PFC WMH volume were associated with ciecreases in PFC activity. In addition, dorsal PFC WMH volume was associated with decreased activity in medial temporal and anterior cingulate regions during episodic retrieval and decreased activity in the posterior parietal and anterior cingulate cortex during working memory performance. These results suggest that disruption of white matter tracts, especially within the PFC, may be a mechanism for age-related changes in memory functioning.
机译：老年人记忆功能的改变通常归因于前额叶皮层（PFC）的功能障碍。这种功能障碍的一种机制可能是破坏了连接PFC及其解剖目标的白质束。在这里，我们测试了白质变性与前额叶激活减少相关的假设。我们将白质高信号（WMH），与老年人脑血管疾病相关的磁共振成像（MRI）发现用作白质变性的标志。具体来说，我们使用结构化MM量化了一组认知正常的老年人中WMH的程度，并测试了这些措施是否可预测发作性检索任务和口头工作记忆任务执行过程中观察到的前额叶活动（fMRI）的程度。我们还检查了背侧前额叶区域中WMH的影响，并提出以下假设：背侧PFC WMH不仅与PFC功能密切相关，而且与与PFC在解剖上和功能上相关的区域也密切相关，这取决于任务方式。结果表明，全球和区域背PFC WMH量的增加均与PFC活性的增加有关。此外，背侧PFC WMH量与情节性检索过程中内侧颞叶和前扣带区活动减少以及工作记忆表现期间顶壁和扣带前皮层活动减少有关。这些结果表明，白质束的破坏，尤其是在PFC内，可能是与年龄相关的记忆功能变化的机制。

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号