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首页> 外文期刊>Journal of environmental science and health >Immunotoxicity of atrazine in Balb/c mice
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Immunotoxicity of atrazine in Balb/c mice

机译：阿特拉津对Balb / c小鼠的免疫毒性

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摘要

The present study was designed to investigate the immunotoxicity of atrazine (ATZ) in male Balb/c mice. ATZ (175, 87.5, and 43.75 mg/kg bw/day) was administered by gavage method for 28 days. The following indexes were determined in various groups of mice: body and organ weight; antibody aggregation of serum hemolysin; proliferative response of splenocytes to Con A; delayed-type hypersensitivity (DTH); natural killer cell activity; clearance of neutral red and nitric oxide (NO) release from peritoneal macrophages; apostosis and necrosis of splenocytes and thymocytes; cytokine production; and serum lysozyme. Results showed that cell-mediated, humoral immunity, and non-specific immune function in the high-dose ATZ group were suppressed; NO release and interferon-γ(IFN-γ)/interleukin-4 (IL-4) were also significantly decreased in the high-dose group. In the medium-dose group, the proliferation response and IFN-γ production was significantly decreased. In the low-dose group, the proliferation response was significantly decreased. Serum lysozyme was decreased in the ATZ-treated groups. The percentage of early apoptosis in thymocytes was increased significantly in high- and medium-dose ATZ groups. In conclusion, ATZ elicited an inhibitory effect on cell-mediated immunity, humoral immunity, and non-specific immune function of mice.
机译：本研究旨在研究阿特拉津（ATZ）对雄性Balb / c小鼠的免疫毒性。通过管饲法给予ATZ（175、87.5和43.75 mg / kg bw /天），持续28天。在各组小鼠中确定以下指标：体重和器官重量；血清溶血素的抗体聚集；脾细胞对Con A的增殖反应；迟发型超敏反应（DTH）；自然杀伤细胞活性；清除腹膜巨噬细胞释放的中性红色和一氧化氮（NO）；脾细胞和胸腺细胞的变性和坏死；细胞因子的产生；和血清溶菌酶。结果显示，高剂量ATZ组的细胞介导的体液免疫和非特异性免疫功能受到抑制；大剂量组NO释放和干扰素-γ（IFN-γ）/白介素-4（IL-4）也显着降低。在中等剂量组中，增殖反应和IFN-γ产生显着降低。在低剂量组中，增殖反应显着降低。在ATZ治疗组中，血清溶菌酶降低了。在大剂量和中剂量的ATZ组中，胸腺细胞中早期凋亡的百分比显着增加。总之，ATZ对小鼠的细胞介导的免疫，体液免疫和非特异性免疫功能均具有抑制作用。

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  • 来源
    《Journal of environmental science and health》 |2013年第9期|637-645|共9页
  • 作者

    JIN Y. CHEN; YANG SONG; LI S. ZHANG;

  • 作者单位

    West China School of Public Health, Sichuan University, P. R. China;

    West China School of Public Health, Sichuan University, P. R. China;

    West China School of Public Health, Sichuan University, P. R. China,West China School of Public Health, Sichuan University, Renmin South Road, Chengdu,Sichuan,P. R.China,610041;

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  • 原文格式 PDF
  • 正文语种 eng
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  • 关键词

    Atrazine; immunotoxicity; cytokines; apoptosis;

    机译：阿特拉津;免疫毒性细胞因子凋亡;

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