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首页> 外文期刊>Journal of Environmental Science and Health >Detection of respiration changes inside biofilms with microelectrodes during exposure to antibiotics
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Detection of respiration changes inside biofilms with microelectrodes during exposure to antibiotics

机译：暴露于抗生素过程中用微电极检测生物膜内部的呼吸变化

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摘要

In order to evaluate the influence of antibiotics on the respiration of subpopulations in biofilms, dissolved oxygen microelectrodes were used to determine the oxygen concentration inside E. Coli biofilms. Based on the results, the oxygen consumption rate varying with depth in the biofilms was calculated before and after the treatment with antibiotics. For both ceftriaxone sodium and chloramphenicol, significant attenuation of oxygen consumption was identified when the system reached steady state. However, by monitoring the oxygen concentration change induced by ceftriaxone sodium, an increased oxygen consumption rate and a shortened oxygen penetration depth were identified in the first few hours, which indicated the accelerated respiration of the subpopulation. Followed by cellular death, the induced respiration acceleration seems to be part of the action mechanism of ceftriaxone sodium. Compared to the planktonic cells, the biofilms showed much higher tolerance to ceftriaxone sodium, which may be attributed to the extended hypoxic zone induced by the accelerated respiration.
机译：为了评估抗生素对生物膜中亚群呼吸的影响，使用溶解氧微电极测定大肠杆菌生物膜内部的氧浓度。根据结果​​，可以计算出抗生素处理前后生物膜中氧气消耗率随深度的变化。对于头孢曲松钠和氯霉素，当系统达到稳定状态时，氧气消耗明显减少。然而，通过监测头孢曲松钠引起的氧浓度变化，在最初的几个小时内发现增加的耗氧速率和缩短的氧渗透深度，这表明亚群的呼吸加快。细胞死亡后，诱导的呼吸加速似乎是头孢曲松钠作用机制的一部分。与浮游细胞相比，生物膜对头孢曲松钠表现出更高的耐受性，这可能归因于由加速呼吸引起的延伸的缺氧区。

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  • 来源
    《Journal of Environmental Science and Health》 |2019年第4期|202-207|共6页
  • 作者

    Lin Jun; Wang Zechen; Zang Yue; Zhang Dong; Xin Qing;

  • 作者单位

    Hangzhou Dianzi Univ, Coll Elect & Informat, Xiasha Campus, Hangzhou, Zhejiang, Peoples R China;

    Hangzhou Dianzi Univ, Coll Elect & Informat, Xiasha Campus, Hangzhou, Zhejiang, Peoples R China;

    Hangzhou Dianzi Univ, Coll Elect & Informat, Xiasha Campus, Hangzhou, Zhejiang, Peoples R China;

    Hangzhou Dianzi Univ, Coll Mat & Environm Engn, Hangzhou, Zhejiang, Peoples R China;

    Hangzhou Dianzi Univ, Coll Elect & Informat, Xiasha Campus, Hangzhou, Zhejiang, Peoples R China;

  • 收录信息 美国《科学引文索引》(SCI);美国《工程索引》(EI);美国《生物学医学文摘》(MEDLINE);美国《化学文摘》(CA);
  • 原文格式 PDF
  • 正文语种 eng
  • 中图分类
  • 关键词

    Microelectrodes; biofilms; ceftriaxone sodium; chloramphenicol;

    机译：微电极;生物膜;头孢曲松钠;氯霉素;

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