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首页> 外文期刊>Journal of Hazardous Materials >Arsenic impacted the development, thyroid hormone and gene transcription of thyroid hormone receptors in bighead carp larvae (Hypophthalmichthys nobilis)
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Arsenic impacted the development, thyroid hormone and gene transcription of thyroid hormone receptors in bighead carp larvae (Hypophthalmichthys nobilis)

机译：砷影响big鱼幼虫（Hypophthalmichthys nobilis）的发育，甲状腺激素和甲状腺激素受体的基因转录

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摘要

Arsenic (As) contamination in aquatic environment adversely impacts aquatic organisms. The present study assessed the toxicity of different As species and concentrations on bighead carp (Hypophthalmichthys nobilis) at early life stage, a major fish in Yangtze River, China. We measured the changes in embryo and larvae survival rate, larvae aberration, concentrations of thyroid hormone thyroxine, and transcription levels of thyroid hormone receptors (TRs) in fish larvae after exposing to arsenite (AsIII) or arsenate (AsV) at 0, 10, 30, 50, 100, or 150 mu g L-1 for 78h. As concentrations <= 150 mu g L-1 had limited effect on embryo survival rate (6-8% inhibition), but larvae survival rate decreased to 53-57% and larvae aberration rate increased to 20-24% after As exposure. Moreover, thyroxine levels elevated by 23% and 50% at 100 mu g L-1 AsIII and 150 mu g L-1 AsV. Besides, AsIII and AsV decreased the transcriptional levels of TR alpha by 72 and 53%, and TR beta by 91 and 81% at 150 mu gL(-1) As. Our data showed that AsIII and AsV had limited effect on carp embryo survival, but they were both toxic to carp larvae, with AsIII showing more effect than AsV. As concentrations <150 mu g L-1 adversely influenced the development of bighead carp larvae and disturbed their thyroid hormone homeostasis. Published by Elsevier B.V.
机译：水生环境中的砷污染会对水生生物产生不利影响。本研究评估了不同砷物种和浓度对big鱼在生命早期阶段的毒性，big鱼是中国长江的主要鱼类。我们在0、10、10、10或10的砷，砷，砷，砷，砷和砷中毒后，测量了鱼幼虫中胚胎和幼虫存活率，幼虫畸变，甲状腺激素甲状腺素的浓度以及甲状腺激素受体（TRs）的转录水平的变化， 30、50、100或150μgL-1持续78h。当浓度<= 150μgL-1对胚胎存活率（6-8％抑制）的作用有限时，但暴露于As后，幼虫存活率降低到53-57％，幼虫畸变率增加到20-24％。此外，在100μg L-1 AsIII和150μgL-1 AsV时，甲状腺素水平分别提高了23％和50％。此外，在150μgL（-1）As下，AsIII和AsV使TR alpha的转录水平降低了72％和53％，TR beta的转录水平降低了91％和81％。我们的数据表明，AsIII和AsV对鲤鱼胚胎存活的作用有限，但它们均对鲤鱼幼虫具有毒性，其中AsIII的作用要强于AsV。当浓度<150μg L-1时，会对big鱼幼虫的发育产生不利影响，并扰乱其甲状腺激素稳态。由Elsevier B.V.发布

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  • 来源
    《Journal of Hazardous Materials》 |2016年第13期|76-82|共7页
  • 作者

    Sun Hong-Jie; Xiang Ping; Tang Ming-Hu; Sun Li; Ma Lena Q.;

  • 作者单位

    Nanjing Univ, Sch Environm, State Key Lab Pollut Control & Resource Reuse, Nanjing 210046, Jiangsu, Peoples R China;

    Nanjing Univ, Sch Environm, State Key Lab Pollut Control & Resource Reuse, Nanjing 210046, Jiangsu, Peoples R China;

    Natl Ind Technol Res Syst Staple Freshwater Fish, Yangzhou Integrated Expt Stn, Yangzhou 225104, Jiangsu, Peoples R China;

    Natl Ind Technol Res Syst Staple Freshwater Fish, Yangzhou Integrated Expt Stn, Yangzhou 225104, Jiangsu, Peoples R China;

    Nanjing Univ, Sch Environm, State Key Lab Pollut Control & Resource Reuse, Nanjing 210046, Jiangsu, Peoples R China|Univ Florida, Dept Soil & Water Sci, Gainesville, FL 32611 USA;

  • 收录信息 美国《科学引文索引》(SCI);美国《工程索引》(EI);美国《生物学医学文摘》(MEDLINE);美国《化学文摘》(CA);
  • 原文格式 PDF
  • 正文语种 eng
  • 中图分类
  • 关键词

    Arsenite; Arsenate; Bighead carp; Early life stage; Thyroid hormone receptors; Thyroid hormone;

    机译：砷;砷;鱼;生命早期;甲状腺激素受体;甲状腺激素;

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