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首页> 外文期刊>Journal of Huazhong University of Science and Technology >Expression and Clinical Significance of p27kip1 Protein in Primary Liver Cancer
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Expression and Clinical Significance of p27kip1 Protein in Primary Liver Cancer

机译：p27kip1蛋白在原发性肝癌中的表达及其临床意义

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摘要

To investigate the expression and clinical significance of p27kip1 protein in primary liver cancer, the expression of p27kip1 protein and the relationship with clinicopathological factors were studied in primary liver cancer by using SABC immunohistochemical staining in specimens of 40 cases of primary liver cancer and 20 cases of liver cirrihosis. Our results showed that positive expression rate of p27kip1 protein in primary liver cancer was 37.5 % (15/40), which was lower than that in benign lesion of liver 80.0 % (16/20, P < 0.01). The expression level of p27kip1 protein in primary liver cancer showed significant differences in tumor size, Edmonson histological grade, portal invasion, lymph node metastasis, TNM stage (P < 0.05, for all), but not significantly correlated with patient's age and histological types. Log rank test showed that the p27kip1 expression was significantly related with prognosis of the patients (P < 0.05), and the prognosis of the patients with p27kip1 positive expression was markedly better than that of those with p27kip1 negative expression. It is concluded that the expression of p27kip1 was significantly related clinicopathological factors of primary liver cancer. p27kip1 protein may be used as a novel tumor marker for primary liver cancer.
机译：为了研究p27kip1蛋白在原发性肝癌中的表达及其临床意义，采用SABC免疫组织化学染色技术对40例原发性肝癌和20例肝癌标本中p27kip1的表达及其与临床病理因素的关系进行了研究。肝硬化。我们的结果表明，p27kip1蛋白在原发性肝癌中的阳性表达率为37.5％（15/40），低于在肝脏良性病变中的80.0％（16/20，P <0.01）。 p27kip1蛋白在原发性肝癌中的表达水平在肿瘤大小，埃德蒙森组织学分级，门静脉侵袭，淋巴结转移，TNM分期方面均存在显着差异（所有P均<0.05），但与患者的年龄和组织学类型无显着相关性。 Log rank检验显示p27kip1表达与患者的预后显着相关（P <0.05），p27kip1表达阳性的患者的预后明显好于p27kip1表达阴性的患者。结论：p27kip1的表达与原发性肝癌的临床病理因素密切相关。 p27kip1蛋白可用作原发性肝癌的新型肿瘤标志物。

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