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首页> 外文期刊>Journal of Materials Research >Antimicrobial hydrogels with controllable mechanical properties for biomedical application
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Antimicrobial hydrogels with controllable mechanical properties for biomedical application

机译：具有可控机械性能的生物医学应用抗菌水凝胶

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摘要

The antibacterial hydrogels can be widely used in the biomedical area owing to their excellent properties. The main limitation of antibacterial hydrogels is their poor mechanical strength. In this study, the novel hydrogels were fabricated with a mixture of silk fibroin (SF), chitosan (CH), agarose (AG), and silver nanoparticles (SNPs) via facile reaction condition without inorganic substances. The mechanical property of these fabricated hydrogels can be modulated by the concentration of SF or AG. The rheological studies demonstrated enhanced elasticity of CH-doped hydrogels. Because of the presence of CH and Ag in hydrogels, the antimicrobial property against gram-positive and gram-negative bacteria was exhibited. Cytocompatibility test proved the very low toxic nature of the hydrogels. In addition, these composite hydrogels have a smaller porosity, higher swelling ratio, and good compatibility, indicating their great potential for biomedical application.
机译：由于其优异的性能，抗菌水凝胶可广泛用于生物医学领域。抗菌水凝胶的主要局限性是其较差的机械强度。在这项研究中，新型的水凝胶是通过丝素蛋白（SF），壳聚糖（CH），琼脂糖（AG）和银纳米颗粒（SNPs）的混合物通过简便的反应条件制备的，而没有无机物质。这些制备的水凝胶的机械性能可以通过SF或AG的浓度来调节。流变学研究表明，掺CH的水凝胶的弹性增强。由于水凝胶中CH和Ag的存在，因此表现出了对革兰氏阳性和革兰氏阴性细菌的抗菌性能。细胞相容性测试证明了水凝胶的毒性很低。另外，这些复合水凝胶具有较小的孔隙率，较高的溶胀率和良好的相容性，表明它们在生物医学应用中具有巨大的潜力。

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  • 来源
    《Journal of Materials Research》 |2019年第11期|1911-1921|共11页
  • 作者

    Chen Si-Hao; Li Zhi; Liu Zu-Lan; Cheng Lan; Tong Xiao-Ling; Dai Fang-Yin;

  • 作者单位

    Southwest Univ, State Key Lab Silkworm Genome Biol, Chongqing 400715, Peoples R China|Southwest Univ, Coll Text & Garment, Chongqing Engn Res Ctr Biomat Fiber & Modern Text, Chongqing 400715, Peoples R China;

    Southwest Univ, State Key Lab Silkworm Genome Biol, Chongqing 400715, Peoples R China|Southwest Univ, Coll Text & Garment, Chongqing Engn Res Ctr Biomat Fiber & Modern Text, Chongqing 400715, Peoples R China;

    Southwest Univ, State Key Lab Silkworm Genome Biol, Chongqing 400715, Peoples R China|Southwest Univ, Coll Text & Garment, Chongqing Engn Res Ctr Biomat Fiber & Modern Text, Chongqing 400715, Peoples R China;

    Southwest Univ, State Key Lab Silkworm Genome Biol, Chongqing 400715, Peoples R China|Southwest Univ, Coll Text & Garment, Chongqing Engn Res Ctr Biomat Fiber & Modern Text, Chongqing 400715, Peoples R China|Southwest Univ, Coll Biotechnol, Minist Agr, Key Lab Sericultural Biol & Genet Breeding, Chongqing 400715, Peoples R China;

    Southwest Univ, State Key Lab Silkworm Genome Biol, Chongqing 400715, Peoples R China|Southwest Univ, Coll Biotechnol, Minist Agr, Key Lab Sericultural Biol & Genet Breeding, Chongqing 400715, Peoples R China;

    Southwest Univ, State Key Lab Silkworm Genome Biol, Chongqing 400715, Peoples R China|Southwest Univ, Coll Text & Garment, Chongqing Engn Res Ctr Biomat Fiber & Modern Text, Chongqing 400715, Peoples R China|Southwest Univ, Coll Biotechnol, Minist Agr, Key Lab Sericultural Biol & Genet Breeding, Chongqing 400715, Peoples R China;

  • 收录信息 美国《科学引文索引》(SCI);美国《工程索引》(EI);美国《生物学医学文摘》(MEDLINE);
  • 原文格式 PDF
  • 正文语种 eng
  • 中图分类
  • 关键词

    biomedical; composite; Ag; porosity;

    机译：生物医学;复合材料;银;孔隙度;

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