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首页> 外文期刊>Journal of Materials Research >Antimicrobial hydrogels with controllable mechanical properties for biomedical application
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Antimicrobial hydrogels with controllable mechanical properties for biomedical application

机译：用于生物医学应用的可控机械性能的抗微生物水凝胶

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摘要

The antibacterial hydrogels can be widely used in the biomedical area owing to their excellent properties. The main limitation of antibacterial hydrogels is their poor mechanical strength. In this study, the novel hydrogels were fabricated with a mixture of silk fibroin (SF), chitosan (CH), agarose (AG), and silver nanoparticles (SNPs) via facile reaction condition without inorganic substances. The mechanical property of these fabricated hydrogels can be modulated by the concentration of SF or AG. The rheological studies demonstrated enhanced elasticity of CH-doped hydrogels. Because of the presence of CH and Ag in hydrogels, the antimicrobial property against gram-positive and gram-negative bacteria was exhibited. Cytocompatibility test proved the very low toxic nature of the hydrogels. In addition, these composite hydrogels have a smaller porosity, higher swelling ratio, and good compatibility, indicating their great potential for biomedical application.
机译：由于其优异的性能，抗菌水凝胶可广泛用于生物医学区域。抗菌水凝胶的主要限制是它们的机械强度差。在该研究中，通过丝网纤维素（SF），壳聚糖（CH），琼脂糖（Ag）和银纳米颗粒（SNP）的混合物制备新的水凝胶，通过体内反应条件，无机物质。这些制造的水凝胶的力学性能可以通过SF或Ag的浓度调节。流变研究证明了CH掺杂水凝胶的增强弹性。由于水凝胶中的CH和Ag存在，表现出针对革兰氏阳性和革兰氏阴性细菌的抗微生物性质。细胞偶联试验证明了水凝胶的极低毒性。此外，这些复合水凝胶具有较小的孔隙率，较高的溶胀比和良好的相容性，表明它们对生物医学应用的巨大潜力。

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  • 来源
    《Journal of Materials Research》 |2019年第11期|1911-1921|共11页
  • 作者

    Chen Si-Hao; Li Zhi; Liu Zu-Lan; Cheng Lan; Tong Xiao-Ling; Dai Fang-Yin;

  • 作者单位

    Southwest Univ State Key Lab Silkworm Genome Biol Chongqing 400715 Peoples R China|Southwest Univ Coll Text & Garment Chongqing Engn Res Ctr Biomat Fiber & Modern Text Chongqing 400715 Peoples R China;

    Southwest Univ State Key Lab Silkworm Genome Biol Chongqing 400715 Peoples R China|Southwest Univ Coll Text & Garment Chongqing Engn Res Ctr Biomat Fiber & Modern Text Chongqing 400715 Peoples R China;

    Southwest Univ State Key Lab Silkworm Genome Biol Chongqing 400715 Peoples R China|Southwest Univ Coll Text & Garment Chongqing Engn Res Ctr Biomat Fiber & Modern Text Chongqing 400715 Peoples R China;

    Southwest Univ State Key Lab Silkworm Genome Biol Chongqing 400715 Peoples R China|Southwest Univ Coll Text & Garment Chongqing Engn Res Ctr Biomat Fiber & Modern Text Chongqing 400715 Peoples R China|Southwest Univ Coll Biotechnol Minist Agr Key Lab Sericultural Biol & Genet Breeding Chongqing 400715 Peoples R China;

    Southwest Univ State Key Lab Silkworm Genome Biol Chongqing 400715 Peoples R China|Southwest Univ Coll Biotechnol Minist Agr Key Lab Sericultural Biol & Genet Breeding Chongqing 400715 Peoples R China;

    Southwest Univ State Key Lab Silkworm Genome Biol Chongqing 400715 Peoples R China|Southwest Univ Coll Text & Garment Chongqing Engn Res Ctr Biomat Fiber & Modern Text Chongqing 400715 Peoples R China|Southwest Univ Coll Biotechnol Minist Agr Key Lab Sericultural Biol & Genet Breeding Chongqing 400715 Peoples R China;

  • 收录信息 美国《科学引文索引》(SCI);美国《工程索引》(EI);美国《生物学医学文摘》(MEDLINE);
  • 原文格式 PDF
  • 正文语种 eng
  • 中图分类
  • 关键词

    biomedical; composite; Ag; porosity;

    机译：生物医学;复合;AG;孔隙度;

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