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首页> 外文期刊>Journal of Materials Research >Biomimetic synthesis of vaterite CaCO_3 microspheres under threonine for preparation of pH-responsive antibacterial biofilm
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Biomimetic synthesis of vaterite CaCO_3 microspheres under threonine for preparation of pH-responsive antibacterial biofilm

机译：苏氨酸下Vaterite Caco_3微球的仿生合成制备pH值抗菌生物膜

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摘要

The synthesis of antibacterial biomaterial with specific functions responsive to specific bacterial growth environments is of significant importance to achieve effective sterilization and reduce the resistant bacteria. Herein, inspired by biomineralization, we develop a one-pot, threonine (Thr)-mediated biomineralization method using a CO_2 bubbling procedure to green, simply and quickly prepare vaterite CaCO_3 microspheres as a platform for antibacterial Sanguinarine (SAN) delivery. The loading capacity of vaterite CaCO_3 microspheres for SAN drugs reached 159.8 mg/g, corresponding to the loading efficiency of 83.7%. And for the first time, a novel Sanguinarine@calcium carbonate (SAN@CaCO_3) organic-inorganic hybrid antibacterial biofilm was constructed by using vaterite CaCO_3 microspheres with pH-responsive and high SAN drug-loading. Importantly, the film showed bacteria-triggered, pH-responsive SAN release properties and strong bactericidal ability (96.19%) for Staphylococcus aureus (5. aureus). Meanwhile, it also had antibacterial capabilities in real environments. In 7 days, it can significantly inhibit the adhesion and growth of bacteria in the air. The biomineralized synthetic vaterite CaCO_3 microspheres and the application in the construction of pH-responsive antibacterial biofilm have bright future in resisting bacterial infections and reducing the production of resistant bacteria.
机译：响应于特异性细菌生长环境的特异性函数的抗菌生物材料的合成具有重要意义，以实现有效的灭菌并减少抗性细菌。在此，通过生物碳化的启发，我们使用CO_2起泡方法对绿色制育一锅，苏氨酸（THR）介导的方法，简单并迅速制备Vaterite CaCo_3微球作为抗菌性血征（SAN）递送的平台。用于SAN药物的Vaterite Caco_3微球的负载能力达到159.8mg / g，对应于83.7％的负载效率。并首次采用具有pH响应性和高SAN药物载荷的Vaterite Caco_3微球构建了一种新的Sanguinarine @碳酸钙（San @ CaCO_3）有机 - 无机杂化抗菌抗菌生物膜。重要的是，该薄膜显示出细菌触发的pH-响应性SAN释放性能和强烈的杀菌能力（96.19％）用于金黄色葡萄球菌（5.金黄色葡萄球菌）。同时，它在真实环境中也具有抗菌能力。在7天内，它可以显着抑制空气中细菌的粘附性和生长。生物丙原合成vateriteCaco_3微球和在pH响应抗菌生物膜的构建中的应用在抵抗细菌感染并减少抗性细菌的产生方面具有光明的未来。

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  • 来源
    《Journal of Materials Research》 |2020年第18期|2427-2440|共14页
  • 作者

    Tingyu Yang; Yu Wu; Xiaoqing Yue; Cuiyan Wang; Jianbin Zhang;

  • 作者单位

    College of Chemical Engineering Inner Mongolia University of Technology Hohhot 010051 China Inner Mongolia Engineering Research Center for CO_2 Capture and Utilization Hohhot 010051 China;

    College of Chemical Engineering Inner Mongolia University of Technology Hohhot 010051 China Inner Mongolia Engineering Research Center for CO_2 Capture and Utilization Hohhot 010051 China;

    College of Chemical Engineering Inner Mongolia University of Technology Hohhot 010051 China Inner Mongolia Engineering Research Center for CO_2 Capture and Utilization Hohhot 010051 China;

    College of Chemical Engineering Inner Mongolia University of Technology Hohhot 010051 China Inner Mongolia Engineering Research Center for CO_2 Capture and Utilization Hohhot 010051 China;

    College of Chemical Engineering Inner Mongolia University of Technology Hohhot 010051 China Inner Mongolia Engineering Research Center for CO_2 Capture and Utilization Hohhot 010051 China;

  • 收录信息 美国《科学引文索引》(SCI);美国《工程索引》(EI);美国《生物学医学文摘》(MEDLINE);
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