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首页> 外文期刊>Journal of Materials Research >A simple in situ synthesis of iron oxide magnetic nanoparticles embedded in thermosensitive polymer for DNA capture
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A simple in situ synthesis of iron oxide magnetic nanoparticles embedded in thermosensitive polymer for DNA capture

机译：一种简单的原位合成嵌入热敏聚合物中的氧化铁磁性纳米粒子进行DNA捕获

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摘要

In this study, we report a simple one-pot synthesis of iron oxide nanoparticles (IONPs) modified with thermoresponsive polymers potentially applicable for nucleic acid capture. Ferrous (Fe~(2+)) and ferric (Fe~(3+)) ions were coprecipitated to a dispersion of previously prepared poly(N-isopropylacrylamide-co-2-aminoethyl methacrylate) P(NIPAAm-co-AEM) for in situ synthesis of magnetite (Fe_3O_4) and concurrent surface modification of Fe_3O_4 with the polymer to obtain magnetic nanocomposites. Fourier-transform infrared (FTIR) spectroscopy analysis reveals the surface modification of Fe_3O_4 with P(NIPAAm-co-AEM) and P(NIPAAm) as functional and control polymers, respectively. Fe_3O_4@P(NIPAAm-co-AEM) and Fe_3O_4@P(NIPAAm) nanocomposites' surfaces contain 7.5 and 2.3 wt% of immobilized polymers, respectively. Vibrating sample magnetometry (VSM) result indicates a high saturation of magnetization value, 75 emu/g, for Fe_3O_4@P(NIPAAm-co-AEM) nanocomposites. The hydrodynamic diameter of Fe_3O_4@P(NIPAAm-co-AEM) in water changes depending on pH and temperature. A study for deoxyribonucleic acid (DNA) capture ability of Fe_3O_4@P(NIPAAm-co-AEM) nanocomposites shows a maximum 18.5 mg/g of DNA can be adsorbed on Fe_3O_4@P(NIPAAm-co-AEM).
机译：在这项研究中，我们报告了一种简单的单罐合成氧化铁纳米颗粒（IONP），其具有可能适用于核酸捕获的热响应性聚合物。将铁（Fe〜（2+））和铁（Fe〜（3+））离子共沉淀至先前制备的聚（N-异丙基丙烯酰胺-CO-2-氨基乙基甲基丙烯酸酯）p（NIPAAM-CO-AEM）的分散体原位合成磁铁矿（Fe_3O_4）和具有聚合物的Fe_3O_4的并发表面改性，得到磁性纳米复合材料。傅立叶变换红外（FTIR）光谱分析揭示了具有P（NIPAAM-AEM）和P（NIPAAM）作为功能和对照聚合物的Fe_3O_4的表面修饰。 FE_3O_4 @ P（NIPAAM-CO-AEM）和FE_3O_4 @ P（NIPAAM）纳米复合材料的表面分别包含7.5和2.3wt％的固定化聚合物。振动样品磁体（VSM）结果表明Fe_3O_4（NIPAam-Co-AEM）纳米复合材料的磁化值，75 emu / g的高饱和度。根据pH和温度，水变化中Fe_3O_4 @ P（NIPAam-Co-AEM）的流体动力直径。 Fe_3O_4 @ P（NIPAAM-CO-AEM）纳米复合材料的脱氧核糖核酸（DNA）捕获能力的研究表明，最大18.5mg / g可吸附在Fe_3O_4 @ P（NIPAAM-CO-AEM）上吸附。

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  • 来源
    《Journal of Materials Research》 |2020年第18期|2441-2450|共10页
  • 作者

    Sadia Hossain; Mahbubor Rahman; Yeasmin Nahar; Abdur Rahman; Mostafa Kaiyum Sharafat; Motahar Hossain; Bungo Ochiai; Abdelhamid Elaissari; Hasan Ahmad;

  • 作者单位

    Research Laboratory of Polymer Colloids & Nanomaterials Department of Chemistry Faculty of Science Rajshahi University Rajshahi 6205 Bangladesh;

    Research Laboratory of Polymer Colloids & Nanomaterials Department of Chemistry Faculty of Science Rajshahi University Rajshahi 6205 Bangladesh Advance Materials Research Laboratory Department of Materials Science and Engineering Clemson University Clemson SC 29625-0971 USA;

    Research Laboratory of Polymer Colloids & Nanomaterials Department of Chemistry Faculty of Science Rajshahi University Rajshahi 6205 Bangladesh;

    Research Laboratory of Polymer Colloids & Nanomaterials Department of Chemistry Faculty of Science Rajshahi University Rajshahi 6205 Bangladesh;

    Department of Chemistry Begum Rokeya University Rangpur Bangladesh;

    Research Laboratory of Polymer Colloids & Nanomaterials Department of Chemistry Faculty of Science Rajshahi University Rajshahi 6205 Bangladesh;

    Department of Chemistry and Chemical Engineering Graduate School of Science and Engineering Yamagata University Yonezawa Japan;

    Laboratory of Automatic Control Chemical and Pharmaceutical Engineering (LAGEP)-Lyon University of Lyon 1 Villeurbanne Cedex 69622 France;

    Research Laboratory of Polymer Colloids & Nanomaterials Department of Chemistry Faculty of Science Rajshahi University Rajshahi 6205 Bangladesh;

  • 收录信息 美国《科学引文索引》(SCI);美国《工程索引》(EI);美国《生物学医学文摘》(MEDLINE);
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