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首页> 外文期刊>Journal of Materials Research >Hyaluronan-coated meta-organic framework loaded with cisplatin and oleanolic acid for synergetic chemotherapy of colorectal cancer
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Hyaluronan-coated meta-organic framework loaded with cisplatin and oleanolic acid for synergetic chemotherapy of colorectal cancer

机译：透明质酸涂层的荟萃有机骨架，配以顺铂和烯醇酸，用于共直肠癌的协同化疗

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摘要

Effective cancer therapy is usually limited by the off target distribution of chemotherapeutic drugs and multidrug resistance (MDR) of cancer cells. As a result, the development of a drug delivery system (DDS) capable of targeting cancer cells while at the same time delivering two or more chemotherapeutic drugs is believed to be a good solution to this dilemma. Herein, a hyaluronan-coated meta-organic framework nanoparticles (HM) were fabricated as a DDS in our study to deliver cisplatin (PDD) and oleanolic acid (Ola). Positive results were obtained in our study which reveal that the DDS (HM/PDD/Ola) is favorable in colorectal cancer (HCT116) therapy by enhancing targeted apoptosis and reversing MDR. Compared with applying free drugs or mono DDS, the dual loaded HM/PDD/Ola showed synergistic effects and better performance, which might be a future alternative for the chemotherapy of colorectal cancer.
机译：有效的癌症治疗通常受到癌细胞化学治疗药物和多药物耐药性（MDR）的靶向分布的限制。结果，在递送两种或更多种化学治疗药物的同时，能够靶向癌细胞的药物递送系统（DDS）的发展被认为是这种困境的良好溶液。在此，在我们的研究中制备透明质酸涂覆的荟萃有机骨架纳米颗粒（HM），以递送顺铂（PDD）和OleAlic酸（OLA）。在我们的研究中获得了阳性结果，揭示了DDS（HM / PDD / OLA）通过增强靶向细胞凋亡和逆转MDR来治疗结直肠癌（HCT116）治疗。与施用游离药物或单声道DDS相比，双重负载的HM / PDD / OLA表现出协同效应和更好的性能，这可能是结直肠癌化疗的未来替代方案。

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  • 来源
    《Journal of Materials Research》 |2020年第22期|3106-3115|共10页
  • 作者

    Qin Huang; En Wang; Weigang Gu; Wencong Ma; Yifeng Zhou;

  • 作者单位

    Department of Gastroenterology Enze Hospital Taizhou Enze Medical Center (Group) Taizhou Zhejiang Province 318050 China;

    Department of Gastroenterology Enze Hospital Taizhou Enze Medical Center (Group) Taizhou Zhejiang Province 318050 China;

    Department of Gastroenterology Affiliated Hangzhou First People's Hospital Zhejiang University School of Medicine Hangzhou Zhejiang Province 310006 China;

    Department of Gastroenterology Affiliated Hangzhou First People's Hospital Zhejiang University School of Medicine Hangzhou Zhejiang Province 310006 China;

    Department of Gastroenterology Affiliated Hangzhou First People's Hospital Zhejiang University School of Medicine Hangzhou Zhejiang Province 310006 China;

  • 收录信息 美国《科学引文索引》(SCI);美国《工程索引》(EI);美国《生物学医学文摘》(MEDLINE);
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  • 正文语种 eng
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