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首页> 外文期刊>Journal of Materials Research >3D printing of poly(ε-caprolactone)/poly(D,L-lactide-co-glycolide)/ hydroxyapatite composite constructs for bone tissue engineering
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3D printing of poly(ε-caprolactone)/poly(D,L-lactide-co-glycolide)/ hydroxyapatite composite constructs for bone tissue engineering

机译：用于骨组织工程的聚（ε-己内酯）/聚（D，L-丙交酯-乙交酯）/羟基磷灰石复合构造的3D打印

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Three-dimensional (3D) printing technology is a promising method for bone tissue engineering applications. For enhanced bone regeneration, it is important to have printable ink materials with appealing properties such as construct interconnectivity, mechanical strength, controlled degradation rates, and the presence of bioactive materials. In this respect, we develop a composite ink composed of polycaprolactone (PCL), poly(D,L-lactide-co-glycolide) (PLGA), and hydroxyapatite particles (HAps) and 3D print it into porous constructs. In vitro study revealed that composite constructs had higher mechanical properties, surface roughness, quicker degradation profile, and cellular behaviors compared to PCL counterparts. Furthermore, in vivo results showed that 3D-printed composite constructs had a positive influence on bone regeneration due to the presence of newly formed mineralized bone tissue and blood vessel formation. Therefore, 3D printable ink made of PCL/PLGA/HAp can be a highly useful material for 3D printing of bone tissue constructs.
机译：三维（3D）打印技术是用于骨组织工程应用的一种有前途的方法。为了增强骨骼再生，重要的是要具有可吸引的特性的可印刷油墨材料，例如构造互连，机械强度，受控的降解速率以及生物活性材料的存在。在这方面，我们开发了一种由聚己内酯（PCL），聚（D，L-丙交酯-共-乙交酯）（PLGA）和羟基磷灰石颗粒（HAps）组成的复合墨水，并将其3D打印到多孔结构中。体外研究表明，与PCL同类产品相比，复合材料构造物具有更高的机械性能，表面粗糙度，更快的降解曲线和细胞行为。此外，体内结果显示，由于存在新形成的矿化骨组织和血管形成，因此3D打印的复合结构对骨再生具有积极影响。因此，由PCL / PLGA / HAp制成的3D可打印墨水对于骨骼组织构建体的3D打印可以是非常有用的材料。

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