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首页> 外文期刊>Journal of Materials Research >Nanoindentation of bone: Comparison of specimens tested in liquid and embedded in polymethylmethacrylate
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Nanoindentation of bone: Comparison of specimens tested in liquid and embedded in polymethylmethacrylate

机译：骨的纳米压痕：在液体中测试并包埋在聚甲基丙烯酸甲酯中的标本的比较

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摘要

Elastic modulus of bone was investigated by nanoindentation using common methods of sample preparation, data collection, and analysis, and compared to dynamic mechanical analysis (DMA: three-point bending) for the same samples. Nanoindentation (Berkovich, 5 mu m and 21 mu m radii spherical indenters) and DMA were performed on eight wet and dehydrated (100 percent ethanol), machined equine cortical bone beams. Samples were embedded in polymethylmethacrylate (PMMA) and mechanical tests repeated. Indentation direction was transverse to the bone long axis while DMA tested longitudinally, giving approximately 12 percent greater modulus in DMA. For wet samples, nanoindentation with spherical indenters revealed a low modulus surface layer. Estimates of the volume of material contributing to elastic modulus measurement showed that the surface layer influences the measured modulus at low loads. Consistent results were obtained for embedded tissue regardless of indenter geometry, provided appropriate methods and analysis were used. Modulus increased for nanoindentation (21 mu m radius indenter) from 11.7 GPa +- 1.7 to 15.0 GPa +- 2.2 to 19.4 GPa +- 2.1 for wet, dehydrated in ethanol, and embedded conditions, respectively. The large increases in elastic modulus caused by replacing water with ethanol and ethanol with PMMA demonstrate that the role of water in fine pore space and its interaction with collagen strongly influence the mechanical behavior of the tissue.
机译：使用常见的样品制备，数据收集和分析方法，通过纳米压痕研究了骨骼的弹性模量，并与相同样品的动态力学分析（DMA：三点弯曲）进行了比较。纳米压痕（Berkovich，半径为5微米和21微米的球形球形压头）和DMA在八根湿的和脱水的（100％乙醇）机加工的马皮质骨束上进行。将样品包埋在聚甲基丙烯酸甲酯（PMMA）中，并重复进行机械测试。压痕方向横向于骨长轴，而DMA进行纵向测试，则DMA中的模量提高了约12％。对于湿样品，具有球形压头的纳米压痕显示出低模量的表面层。对有助于弹性模量测量的材料体积的估计表明，在低载荷下，表面层会影响所测量的模量。不管压头的几何形状如何，只要使用适当的方法和分析，就可以获得包埋组织的一致结果。纳米压痕（半径为21微米的压头）的模量从湿，在乙醇中脱水和嵌入条件下分别从11.7 GPa +-1.7增加到15.0 GPa +-2.2到19.4 GPa +-2.1。通过用乙醇代替水和用PMMA代替乙醇引起的弹性模量的大幅提高表明，水在细孔空间中的作用及其与胶原的相互作用强烈影响组织的机械行为。

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  • 来源
    《Journal of Materials Research》 |2004年第1期|p.249-259|共11页
  • 作者

    A.J. Bushby; V.L. Ferguson; A. Boyde;

  • 作者单位

    Department of Materials, Queen Mary, University of London, London E1 4NS, United Kingdom;

  • 收录信息 美国《科学引文索引》(SCI);美国《工程索引》(EI);美国《生物学医学文摘》(MEDLINE);
  • 原文格式 PDF
  • 正文语种 eng
  • 中图分类 工程材料学;
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