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首页> 外文期刊>Journal of Materials Science >Synthesis and applications of fluorescent-magnetic-bifunctional dansylated Fe3O4@SiO2 nanoparticles
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Synthesis and applications of fluorescent-magnetic-bifunctional dansylated Fe3O4@SiO2 nanoparticles

机译：荧光-磁性双功能丹磺化Fe3 O4 @ SiO2 纳米粒子的合成及应用

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摘要

Bifunctional magnetic-luminescent dansylated Fe3O4@SiO2 (Fe3O4@SiO2-DNS) nanoparticles were fabricated by the nucleophilic substitution of dansyl chloride with primary amines of aminosilane-modified Fe3O4@SiO2 core–shell nanostructures. The morphology and properties of the resultant Fe3O4@SiO2-DNS nanoparticles were investigated by transmission electron microscopy, FT–IR spectra, UV–vis spectra, photoluminescence spectra, and vibrating sample magnetometry. The Fe3O4@SiO2-DNS nanocomposites exhibit superparamagnetic behavior at room temperature, and can emit strong green light under the excitation of UV light. They show very low cytotoxicity against HeLa cells and negligible hemolysis activity. The T 2 relaxivity of Fe3O4@SiO2-DNS in water was determined to be 114.6 Fe mM−1 s−1. Magnetic resonance (MR) imaging analysis coupled with confocal microscopy shows that Fe3O4@SiO2-DNS can be uptaken by the cancer cells effectively. All these positive attributes make Fe3O4@SiO2-DNS a promising candidate for both MR and fluorescent imaging applications.
机译：丹磺酰基的亲核取代反应制备了双功能的磁致发光丹磺化Fe3 O4 @ SiO2 （Fe3 O4 @ SiO2 -DNS）纳米粒子氨基硅烷改性的Fe3 O4 @ SiO2 核-壳纳米结构的伯胺形成的氯化物。通过透射电子显微镜，FT-IR光谱，UV-vis光谱，光致发光光谱和振动样品磁强分析法研究了所得Fe3 O4 @ SiO2 -DNS纳米粒子的形貌和性质。 Fe3 O4 @ SiO2 -DNS纳米复合材料在室温下表现出超顺磁性，在紫外光的激发下可以发出强烈的绿光。它们显示出对HeLa细胞极低的细胞毒性，溶血活性可忽略不计。 Fe3 O4 @ SiO2 -DNS在水中的T 2 弛豫度确定为114.6 Fe mM-1 s-1 。磁共振成像分析和共聚焦显微镜分析表明，Fe3 O4 @ SiO2 -DNS可以被癌细胞有效摄取。所有这些积极特性使Fe3 O4 @ SiO2 -DNS成为MR和荧光成像应用的有希望的候选者。

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  • 来源
    《Journal of Materials Science》 |2011年第18期|p.5959-5968|共10页
  • 作者

    Gang Liu; Huixia Wu; Haoran Zheng; Lihui Tang; He Hu; Hong Yang; Shiping Yang;

  • 作者单位

    The Key Laboratory of Resource Chemistry of Ministry of Education, College of Life and Environmental Science, Shanghai Normal University, 100 Guilin Road, Shanghai, 200234, People’s Republic of China;

    The Key Laboratory of Resource Chemistry of Ministry of Education, College of Life and Environmental Science, Shanghai Normal University, 100 Guilin Road, Shanghai, 200234, People’s Republic of China;

    The Key Laboratory of Resource Chemistry of Ministry of Education, College of Life and Environmental Science, Shanghai Normal University, 100 Guilin Road, Shanghai, 200234, People’s Republic of China;

    The Key Laboratory of Resource Chemistry of Ministry of Education, College of Life and Environmental Science, Shanghai Normal University, 100 Guilin Road, Shanghai, 200234, People’s Republic of China;

    The Key Laboratory of Resource Chemistry of Ministry of Education, College of Life and Environme;

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