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首页> 外文期刊>Journal of Medical Virology >Human papillomavirus type distribution in vulval intraepithelial neoplasia determined using PapilloCheck DNA Microarray
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Human papillomavirus type distribution in vulval intraepithelial neoplasia determined using PapilloCheck DNA Microarray

机译：使用PapilloCheck DNA芯片确定外阴上皮内瘤变中人乳头瘤病毒的类型分布

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Vulval intraepithelial neoplasia is a precursor of vulval carcinoma, and is frequently associated with human papillomavirus (HPV) infection. Estimates of HPV prevalence in vulval intraepithelial neoplasia vary widely in the UK. The objective of this study was to assess HPV infection in a sample of women with vulval intraepithelial neoplasia, confirmed histologically, and determine the proportion of disease associated with HPV types targeted by prophylactic HPV vaccines. HPV infection was assessed in biopsies from 59 patients using the Greiner Bio-One PapilloCheck® DNA chip assay. Valid results were obtained for 54 cases. HPV infection was present in 43 of the 54 cases (79.6%: 95% CI 67.1–88.2%). The most common HPV types were HPV 16 (33/54: 61.1%), HPV 33 (8/54: 14.8%), HPV 6 (5/54: 9.3%), and HPV 42 (3/54: 5.6%). The mean age of HPV positive women was significantly less than the mean age of HPV negative women. This is the largest UK series of vulval intraepithelial neoplasia in which HPV type has been investigated, and 34/54 (63.0%, 95% CI: 49.6–78.6%) cases were associated with HPV 16/18, which are targeted by current prophylactic HPV vaccines. J. Med. Virol. 83:1358–1361, 2011. © 2011 Wiley-Liss, Inc.
机译：外阴上皮内瘤变是外阴癌的前体，并经常与人乳头瘤病毒（HPV）感染相关。在英国，外阴上皮内瘤变中HPV患病率的估计差异很大。这项研究的目的是评估具有外阴上皮内瘤样变的女性样本中的HPV感染，在组织学上进行确认，并确定与预防性HPV疫苗靶向的HPV类型相关的疾病比例。使用Greiner Bio-OnePapilloCheck®DNA芯片测定法对59例患者的活检组织中的HPV感染进行了评估。 54例均获得有效结果。 54例病例中有43例存在HPV感染（79.6％：95％CI 67.1-88.2％）。最常见的HPV类型为HPV 16（33/54：61.1％），HPV 33（8/54：14.8％），HPV 6（5/54：9.3％）和HPV 42（3/54：5.6％） 。 HPV阳性女性的平均年龄显着小于HPV阴性女性的平均年龄。这是英国最大的外阴上皮内瘤样变系列，已调查了HPV类型，目前已将34/54（63.0％，95％CI：49.6–78.6％）病例与HPV 16/18相关。 HPV疫苗。 J. Med。病毒83：1358–1361，2011年。©2011 Wiley-Liss，Inc.

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