The response of the host microcirculation to bacterial sepsis: does the pathogen matter?

Matthieu Legrand; Eva Klijn; Didier Payen; Can Ince

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The response of the host microcirculation to bacterial sepsis: does the pathogen matter?

机译：宿主微循环对细菌性败血症的反应：病原体重要吗？

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Sepsis results from the interaction between a host and an invading pathogen. The microcirculatory dysfunction is now considered central in the development of the often deadly multiple organ dysfunction syndrome in septic shock patients. The microcirculatory flow shutdown and flow shunting leading to oxygen demand and supply mismatch at the cellular level and the local activation of inflammatory pathways resulting from the leukocyte–endothelium interactions are both features of the sepsis-induced microcirculatory dysfunction. Although the host response through the inflammatory and immunologic response appears to be critical, there are also evidences that Gram-positive and Gram-negative bacteria can exert different effects at the microcirculatory level. In this review we discuss available data on the potential bacterial-specific microcirculatory alterations observed during sepsis.

机译：败血症是由宿主和入侵病原体之间的相互作用引起的。现在认为在脓毒性休克患者中，通常致命的多器官功能障碍综合症的发展中，微循环功能障碍很重要。微循环流关闭和分流导致细胞水平上的氧气需求和供应失配，以及白细胞与内皮之间的相互作用导致的炎症途径的局部激活，都是脓毒症诱发的微循环功能障碍的特征。尽管通过炎症和免疫反应的宿主反应似乎很关键，但也有证据表明革兰氏阳性和革兰氏阴性细菌可以在微循环水平上发挥不同的作用。在这篇综述中，我们讨论了败血症期间观察到的潜在细菌特异性微循环改变的可用数据。

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《Journal of Molecular Medicine》 |2010年第2期|p.127-133|共7页
作者
Matthieu Legrand; Eva Klijn; Didier Payen; Can Ince;
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正文语种 eng
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关键词
Sepsis; Endothelium; Pathogen; Pathophysiology;

机译：败血症;内皮;病原;病理生理学;

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1. The response of the host microcirculation to bacterial sepsis: does the pathogen matter? [J] . Legrand M, Klijn E, Payen D, Journal of molecular medicine: Official organ of the "Gesellschaft Deutscher Naturforscher und Arzte." . 2010,第2期

机译：宿主微循环对细菌性败血症的反应：病原体重要吗？
2. Simultaneous analysis of host and pathogen interactions during an in vivo infection reveals local induction of host acute phase response proteins, a novel bacterial stress response, and evidence of a host-imposed metal ion limited environment [J] . S. Timothy Motley, Brian J. Morrow, Xuejun Liu, Cellular microbiology . 2004,第9期

机译：在体内感染过程中对宿主和病原体相互作用的同时分析揭示了宿主急性期反应蛋白的局部诱导，新型细菌应激反应以及宿主施加的金属离子受限环境的证据
3. BACTERIAL SEPSIS IS A MAJOR CAUSE OF MORTALITY WORLDWIDE. INDIVIDUAL GENE MUTATIONS CAN COMPROMISE THE IMMUNE SYSTEM, FURTHER INCREASING SUSCEPTIBILITY TO BACTERIAL INFECTION. WHETHER HEREDITARY HEMOCHROMATOSIS, A GENETIC DISEASE OF IRON OVERLOAD, AFFECTS THE HOST'S IMMUNE RESPONSE TO BACTERIAL INFECTIONS IS [J] . Wu Qian, Shen Yuanyuan, Tao Yunlong, American Journal of Hematology . 2016,第3期

机译：细菌性败血症是全世界死亡率的主要原因。个别基因突变会损害免疫系统，进一步增加细菌感染的可能性。遗传性铁过氧化物病是遗传性血液病，但这种病会影响宿主对细菌感染的免疫反应
4. New insights into the landscape relationships of host response to bacterial pathogens [C] . Xiaoyao Yin, Lu Han, Hui Bai, International Joint Conference on Neural Networks . 2015

机译：宿主对细菌病原体反应的景观关系的新见解
5. All Hosts are not Created Equal: Variation in Amphibian Responses to an Emerging Fungal Pathogen and Why it Matters. [D] . Gervasi, Stephanie S. 2013

机译：并非所有宿主都是平等的：两栖动物对新兴真菌病原菌的反应及其重要性。
6. The response of the host microcirculation to bacterial sepsis: does the pathogen matter? [O] . Matthieu Legrand, Eva Klijn, Didier Payen, -1

机译：宿主微循环对细菌性败血症的反应：病原体重要吗？
7. The response of the host microcirculation to bacterial sepsis: does the pathogen matter? [O] . Matthieu Legrand, Eva Klijn, Didier Payen, 2010

机译：宿主微循环对细菌性败血症的反应：病原体重要吗？

The response of the host microcirculation to bacterial sepsis: does the pathogen matter?

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