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首页> 外文期刊>Journal of nano research >Hydroxy-terminated Poly(amidoamine) Dendrimers as Nanocarriers for the Delivery of Antioxidants
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Hydroxy-terminated Poly(amidoamine) Dendrimers as Nanocarriers for the Delivery of Antioxidants

机译：羟基封端的聚（酰胺基胺）树状聚合物作为抗氧化剂传递的纳米载体。

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摘要

The clinical application of antioxidants as pharmaceutical agents has been limited in general because of their poor aqueous solubility and inferior stability. According to previous studies, nanocarrier drug delivery systems may provide an alternative way to solve the above problems. In this study, nanoparticle carriers consisting of 6-hydroxy-2, 5, 7, 8-tetramethylchroman-2-carboxylic acid (Trolox) encapsulating hydroxy-terminated poly(amidoamine) dendrimer (PAMAM-OH) were prepared by a self-assembly method and characterized by size, size distribution and morphology. A drug release assay showed that the Trolox release from PAMAM-OH/Trolox exhibits pH dependence. Moreover, the effects of PAMAM-OH/Trolox on cells damaged by tert-butylhydroperoxide were determined by 3-(4, 5-dimethylthizaol-2-yl)-2, 5-diphenyl tetrazolium bromide assay for cell viability, and malonaldehyde assay for membrane lipid peroxidation. The results illustrated that the PAMAM-OH/Trolox can significantly improve cell viability and reduce MDA content compared with those of cells pretreated with free Trolox.
机译：由于抗氧化剂的水溶性差和稳定性差，因此通常限制了其作为药物的临床应用。根据先前的研究，纳米载体药物递送系统可以提供解决上述问题的替代方式。在这项研究中，通过自组装制备了由6-羟基-2、5、7、8-四甲基苯并-2-羧酸（Trolox）包裹羟基封端的聚（酰胺基胺）树状聚合物（PAMAM-OH）组成的纳米颗粒载体。方法，并以大小，大小分布和形态为特征。药物释放试验表明，从PAMAM-OH / Trolox释放的Trolox表现出pH依赖性。此外，通过3-（4,5-二甲基噻唑-2-基）-2、5-二苯基溴化四氮唑溴酸盐测定细胞存活力和丙二醛测定PAMAM-OH / Trolox对叔丁基过氧化氢损伤细胞的作用。膜脂质过氧化结果表明，与用游离Trolox预处理的细胞相比，PAMAM-OH / Trolox可以显着改善细胞活力并降低MDA含量。

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  • 来源
    《Journal of nano research》 |2013年第2013期|66-73|共8页
  • 作者

    Jian Bi; Yanchao Li; Qianfen Zhuang; Zhenhua Leng; Hongying Jia; Yang Liu; Jianwei Zhou; Libo Du;

  • 作者单位

    School of Chemistry and Materials Science, Guizhou Normal University, Guizhou, China;

    State Key Laboratory for Structural Chemistry of Unstable Species, Center for Molecular Science, Institute of Chemistry, Chinese Academy of Sciences, Beijing, China,Laboratory of Molecular Iron Metabolism, College of Life Science, Hebei Normal University, Shijiazhuang, China;

    State Key Laboratory for Structural Chemistry of Unstable Species, Center for Molecular Science, Institute of Chemistry, Chinese Academy of Sciences, Beijing, China;

    School of Chemistry and Materials Science, Guizhou Normal University, Guizhou, China;

    State Key Laboratory for Structural Chemistry of Unstable Species, Center for Molecular Science, Institute of Chemistry, Chinese Academy of Sciences, Beijing, China;

    State Key Laboratory for Structural Chemistry of Unstable Species, Center for Molecular Science, Institute of Chemistry, Chinese Academy of Sciences, Beijing, China;

    School of Chemistry and Materials Science, Guizhou Normal University, Guizhou, China;

    State Key Laboratory for Structural Chemistry of Unstable Species, Center for Molecular Science, Institute of Chemistry, Chinese Academy of Sciences, Beijing, China;

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  • 原文格式 PDF
  • 正文语种 eng
  • 中图分类
  • 关键词

    nanoparticle; dendrimer; antioxidant; Vitamin E; oxidative stress; lipid peroxidation;

    机译：纳米粒子树枝状聚合物抗氧化剂维生素E;氧化应激脂质过氧化;

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