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首页> 外文期刊>Journal of nano research >The Profile of Payload Release from Gold Nanoparticles Modified with a BODIPY®/PEG Mixed Monolayer
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The Profile of Payload Release from Gold Nanoparticles Modified with a BODIPY®/PEG Mixed Monolayer

机译：BODIPY®/ PEG混合单分子膜修饰的金纳米颗粒的有效载荷释放曲线

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摘要

Gold nanoparticles with an average diameter of ～15.5 nm as measured via TEM were functionalised with various amounts of thiol-terminated 5000MW poly (ethylene glycol) (0-37.75 ug/ml), or with a mixed monolayer of thiol-terminated BODIPY and poly (ethylene glycol) (PEG) in various ratios. BODIPY is a fluorescing molecule which was used here as a model payload, while PEG was added to the surface in order to increase nanoparticle stability and biocompatibility. It was observed that the gold nanoparticle surface saturates with PEG at a loading rate of ～15 wt%. Glutathione (GSH) is an antioxidant that occurs as high concentrations inside cells and this can be used to trigger therapeutic payload release therein. The release of BODIPY from nanoparticles functionalised with a mixed monolayer of PEG and BODIPY was investigated at typical intracellular glutathione concentrations. The release profiles were fitted using zero, first order, Higuchi and Reciprocal Powered Time (RPT) models. It was observed that BODIPY release from the surface of nanoparticles capped only with BODIPY and PEG was best described by the RPT and Higuchi models, suggesting diffusion and diffusion-dissolution controlled release. However, the release profile of the nanoparticles capped only with BODIPY did not fit the expected profile due to agglomeration effects. The ratio of BOBIPY to PEG on the surface had a dramatic effect on the release rate. The predicted time to release 50% of the payload compound from the gold nanoparticles displayed a ～500 fold increase for a mixed monolayer prepared with 0.5-18.75 μg/ml of BODIPY-PEG compared to nanoparticle samples prepared with 1.5-6.25 μg/ml of BODIPY-PEG.
机译：通过TEM测量的平均直径为〜15.5 nm的金纳米颗粒用各种量的巯基封端的5000MW聚乙二醇（0-37.75 ug / ml）或巯基封端的BODIPY和聚（乙二醇）（PEG）的各种比例。 BODIPY是一种荧光分子，在这里用作模型有效负载，而PEG被添加到表面以增加纳米粒子的稳定性和生物相容性。观察到金纳米颗粒表面以〜15wt％的负载率被PEG饱和。谷胱甘肽（GSH）是一种抗氧化剂，在细胞内部以高浓度存在，可用于触发治疗性有效载荷的释放。在典型的细胞内谷胱甘肽浓度下，研究了用PEG和BODIPY混合单层功能化的纳米粒子释放BODIPY的情况。使用零阶，一阶，Higuchi和倒数动力时间（RPT）模型拟合释放曲线。观察到RPD和Higuchi模型最好地描述了仅用BODIPY和PEG封端的纳米颗粒表面的BODIPY释放，表明扩散和扩散-溶解控制释放。然而，由于团聚效应，仅用BODIPY封端的纳米颗粒的释放曲线不符合预期的曲线。表面上BOBIPY与PEG的比例对释放速率有显着影响。用0.5-18.75μg/ ml BODIPY-PEG制备的混合单层与用1.5-6.25μg/ ml的纳米颗粒样品相比，从金纳米颗粒释放50％的有效负载化合物的预计时间显示增加了约500倍。 BODIPY-PEG。

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  • 来源
    《Journal of nano research》 |2013年第2013期|16-30|共15页
  • 作者

    Dhiraj Kumar; Isha Mutreja; Brian J. Meenan; Dorian Dixon;

  • 作者单位

    Nanotechnology and Integrated BioEngineering Centre (NIBEC) School of Engineering, University of Ulster Shore Road, Newtownabbey, BT37 OQB, UK;

    Nanotechnology and Integrated BioEngineering Centre (NIBEC) School of Engineering, University of Ulster Shore Road, Newtownabbey, BT37 OQB, UK;

    Nanotechnology and Integrated BioEngineering Centre (NIBEC) School of Engineering, University of Ulster Shore Road, Newtownabbey, BT37 OQB, UK;

    Nanotechnology and Integrated BioEngineering Centre (NIBEC) School of Engineering, University of Ulster Shore Road, Newtownabbey, BT37 OQB, UK;

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  • 正文语种 eng
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  • 关键词

    gold nanoparticles; PEG; BODIPY; release model; Reciprocal Powered Time; Higuchi; controlled release;

    机译：金纳米粒子PEG;身体发布模型;倒数动力时间;gu口;控释;

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