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首页> 外文期刊>Journal of Parasitology >INFLUENCE OF MONENSIN ON CATION INFLUX AND NA+-K+-ATPase ACTIVITY OF EIMERIA TENELLA SPOROZOITES IN VITRO
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INFLUENCE OF MONENSIN ON CATION INFLUX AND NA+-K+-ATPase ACTIVITY OF EIMERIA TENELLA SPOROZOITES IN VITRO

机译：莫能菌素对黄粉虫次生孢子体外阳离子通量及NA + -K + -ATPase活性的影响

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摘要

The experiments were conducted to determine intrasporozoite Na+/K+ concentrations (by AAS) and membrane-bound Na+-K+-ATPase activity (measured by UV-VIS with a Na+-K+-ATPase Detection Kit) of Eimeria tenella sporozoites of the sensitive line (i.e., the parent line, coded as OS) and 2 resistant lines, derived from the parent line (coded as OR125 and OR200), with and without in vitro exposure to monensin. These parameters for OR125 and OR200 were significantly lower than those for OS. In vitro exposure to monensin increased intrasporozoite Na+/K+ concentrations and Na+-K+-ATPase activity, but the stimulation on OS was significantly higher than those on OR125 and OR200, indicating that monensin had less effect on resistant parasites. The results of this study suggest that altered biochemical or physiological properties, or both, in the membranes of E. tenella might be related to a reduced sensitivity to monensin.
机译：进行实验以确定敏感株系艾美球虫子孢子虫的子孢子内Na + / K +浓度（通过AAS）和膜结合Na + -K + -ATPase活性（通过UV-VIS用Na + -K + -ATPase检测试剂盒测量）。即，有或没有体外暴露于莫能菌素的亲本品系（代号为OS）和2个抗性品系（从母系（代号为OR125和OR200）衍生）。 OR125和OR200的这些参数明显低于OS。莫能菌素的体外暴露增加了子孢子体内的Na + / K +浓度和Na + -K + -ATPase活性，但OS的刺激显着高于OR125和OR200，这表明莫能菌素对耐药性寄生虫的影响较小。这项研究的结果表明，改变大肠杆菌中膜的生化或生理特性，或两者都有可能与对莫能菌素的敏感性降低有关。

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