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首页> 外文期刊>Journal of Parasitology >SUPPRESSION OF EXTRAINTESTINAL AND INTESTINAL NIPPOSTRONGYLUS BRASILIENSIS-INDUCED EOSINOPHILIA BY EIMERIA NIESCHULZI
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SUPPRESSION OF EXTRAINTESTINAL AND INTESTINAL NIPPOSTRONGYLUS BRASILIENSIS-INDUCED EOSINOPHILIA BY EIMERIA NIESCHULZI

机译：埃美尔尼氏菌对抑制巴西结节病和肠球菌病引起的巴西嗜酸性粒细胞增多的抑制

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Eosinophil responses in extraintestinal and intestinal tissues were examined in August and Sprague-Dawley rats infected with Nippostrongylus brasiliensis or Eimeria nieschulzi (or both), and in uninfected controls to test the hypothesis that E. nieschulzi suppresses the systemic N. brasiliensis-induced eosinophil response. Caudal vein blood, femoral bone marrow, bronchoalveolar lavage fluid, peritoneal lavage fluid, and duodenal and jejunal samples were collected on day 8 postinfection (PI) with E. nieschulzi, on day 16 PI of the N. brasiliensis infection, when these days coincided in the concurrently infected rats, and from uninfected controls. Differential white blood cell counts were made from blood smears and cytocentrifuged preparations, and duodenal and jejunal eosinophils per villus crypt unit were quantified. Eimeria nieschulzi significantly reduced N. brasiliensis-induced eosinophil levels in peripheral blood, lavage fluids, and duodenal and jejunal tissues in both rat strains. August and Sprague-Dawley rats monospecifically infected with N. brasiliensis and concurrently with both parasites demonstrated elevated eosinopoiesis compared with uninfected controls and rats infected with only E. nieschulzi; however, despite this, concurrently infected rats had a significantly greater level of eosinopoiesis than those infected with only the nematode. In addition, E. nieschulzi induced elevated neutrophil levels in both monospecifically and concurrently infected rats in all extraintestinal tissues examined in both rat strains, whereas lymphocyte counts decreased concomitantly. This study suggests that the intestinal coccidian E. nieschulzi has the ability to modulate the systemic inflammatory response to N. brasiliensis and that this is not a rat strain-specific phenomenon.
机译：在八月检查了肠外和肠组织中的嗜酸性粒细胞反应，并在感染了巴西夜蛾或尼美氏球虫（或两者）的Sprague-Dawley大鼠中进行了检查，并在未感染的对照中进行了测试，以检验尼希氏菌抑制系统性巴西芥诱导的嗜酸性粒细胞反应的假说。 。在感染巴西尼氏肠杆菌的感染后（PI）第8天（PI），在感染后第8天（PI），收集尾静脉血，股骨髓，支气管肺泡灌洗液，腹膜灌洗液以及十二指肠和空肠样本在并发感染的大鼠中，以及未感染的对照中。由血液涂片和细胞离心制备物进行白细胞差异计数，并对每个绒毛隐窝单位的十二指肠和空肠嗜酸性粒细胞进行定量。聂氏艾美尔球虫（Eimeria nieschulzi）显着降低了两种大鼠品系中巴西猪笼草诱导的外周血，灌洗液以及十二指肠和空肠组织中嗜酸性粒细胞水平。与未感染的对照组和仅感染了聂氏肠球菌的大鼠相比，August和Sprague-Dawley大鼠单特异性感染了巴西猪笼草并同时感染了两种寄生虫。但是，尽管如此，并发感染的大鼠的嗜曙红细胞生成水平比仅线虫感染的大鼠高得多。另外，在两种大鼠品系中检查的所有肠外组织中，尼舒尔肠炎球菌均在单特异性感染和同时感染的大鼠中诱导中性粒细胞水平升高，而淋巴细胞计数随之降低。这项研究表明，肠球虫埃希氏大肠杆菌具有调节对巴西猪笼草的全身炎症反应的能力，这不是大鼠品系特异性现象。

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