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首页> 外文期刊>Journal of Parasitology >RESPIRATORY BURST OF BIOMPHALARIA GLABRATA HEMOCYTES: SCHISTOSOMA MANSONI–RESISTANT SNAILS PRODUCE MORE EXTRACELLULAR H2O2 THAN SUSCEPTIBLE SNAILS
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RESPIRATORY BURST OF BIOMPHALARIA GLABRATA HEMOCYTES: SCHISTOSOMA MANSONI–RESISTANT SNAILS PRODUCE MORE EXTRACELLULAR H2O2 THAN SUSCEPTIBLE SNAILS

机译：伯氏冈氏菌血细胞的呼吸爆发：抵抗血吸虫曼森氏菌的胞外H2O2比易感树突更多

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摘要

The production of reactive oxygen species by hemocytes from the gastropod Biomphalaria glabrata has been linked to their ability to kill the trematode parasite Schistosoma mansoni. For 2 laboratory strains of the snail, 1 resistant (13-16-R1) and 1 susceptible (MO) to the PR1 strain of S. mansoni, we compared hemocyte production of extracellular hydrogen peroxide when stimulated with the protein kinase C agonist phorbol myristate acetate (PMA). The time course of the PMA-induced response is similar in both strains with respect to onset, peak production, and termination of the respiratory burst. However, the magnitude of the response differs between strains, in that hemocytes from resistant snails generate significantly more hydrogen peroxide. These findings suggest that the capacity to produce hydrogen peroxide could be critical in determining susceptibility or resistance to S. mansoni.
机译：腹足纲小生虫（Biomphalaria glabrata）的血细胞产生活性氧物种，已与它们杀死曼氏血吸虫寄生虫的能力有关。对于2种实验室蜗牛，对曼氏葡萄球菌PR1菌株具有1个抗性（13-16-R1）和1个敏感（MO），我们比较了在蛋白激酶C激动剂佛波肉豆蔻酸酯刺激下细胞外过氧化氢的血细胞生成。醋酸盐（PMA）。在两种毒株中，PMA诱导反应的时间过程在呼吸爆发的发作，峰值产生和终止方面相似。但是，不同菌株之间的反应强度不同，因为来自抗性蜗牛的血细胞会产生更多的过氧化氢。这些发现表明，产生过氧化氢的能力对于确定曼氏葡萄球菌的敏感性或抗性至关重要。

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