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Layer by Layer Photo-Cross-Linked Environmental Functional hydrogel Thin Films Based on Vanillin: Part 3

机译:基于香兰素的逐层光交联环境功能水凝胶薄膜:第3部分

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The present work emphasizes the preparation of new monomer from the family of vanillin acrylate. It has been prepared in two steps the name of the final product is [2-((ditert-butylamino) methyl)-4-formyl-6-methoxyphenyl acrylate] and abbreviated by TBAMVA, both products were evaluated by H-1, C-13 NMR and FTIR and they were in the logic case with the chemical structure. The next step was the preparation of three different pH and temperature responsive copolymers by free radical polymerization of 5, 10, 20mol% of TBAMVA and 5mol% of maleimide photo-cross-linker with N-isopropylacrylamide. Polymers were chemically and physically characterized indicating the presence of the aldehyde group in the main chain. The lower critical solution temperature of polymers has been determined by two methods; the first one using turbidity measurements by UV-Vis Spectroscopy, another method using micro-DSC. The last step was the formation of pH-Temperature responsive hydrogel layer over gold and studying the swelling properties response to pH and temperature using surface plasmon resonance with the optical waveguide. In the present work, we focused on synthesizing new environmental functional polymers and hydrogel thin films used as biosensor as a target for many biological molecules in biosynthesis, drug delivery, and bio-separation.
机译:本工作着重从香草醛丙烯酸酯家族制备新单体。分两步制备,最终产物的名称为[2-((二叔丁基氨基)甲基)-4-甲酰基-6-甲氧基苯基丙烯酸酯],简称TBAMVA,两种产物均通过H-1,C评估-13 NMR和FTIR在逻辑上具有化学结构。下一步是通过5、10、20mol%的TBAMVA和5mol%的马来酰亚胺光交联剂与N-异丙基丙烯酰胺的自由基聚合,制备三种不同的pH和温度响应型共聚物。对聚合物进行了化学和物理表征,表明主链中存在醛基。聚合物的较低临界溶液温度已通过两种方法确定:第一种方法是使用UV-Vis光谱法测量浊度,另一种方法是使用微型DSC。最后一步是在金上形成pH温度响应水凝胶层,并使用表面等离振子与光波导的共振来研究对pH和温度的溶胀特性。在当前的工作中,我们专注于合成用作生物传感器的新型环境功能聚合物和水凝胶薄膜,将其作为生物合成,药物递送和生物分离中许多生物分子的目标。

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