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首页> 外文期刊>Journal of Polymers and the Environment >Production of Hydrogel Microneedles from Fish Scale Biopolymer
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Production of Hydrogel Microneedles from Fish Scale Biopolymer

机译：来自鱼鳞生物聚合物的水凝胶微针的生产

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摘要

This work presents for the first time, a scalable, low cost method for producing hydrogel microneedles from fish scales derived biopolymer using a modified low temperature press method. The microneedles are made from cross-linked hydrolyzed collagen (HC). The suitability of the microneedles for drug loading were tested by loading with Ferrous gluconate. Force analysis carried out in compression mode showed that the microneedles could withstand up to 0.136N per microneedle before fracture which is sufficient strength to pierce the skin. The cross-linked microneedles swelled to 340% of their original mass in PBS and within 24h released 34.5% of the loaded drug, while the non cross-linked microneedles dissolved within minutes. Chemical testing of the released drug confirmed that the drug released retained its chemical structure by forming colored complex with acetylsalicylic acid and UV spectrometry was used to quantify the concentration released. FTIR analysis confirmed the modified structure of the polymer when cross-linked. This proposed method allows cross-linking at room temperature using a thermal press method which can be easily scaled up.
机译：该工作首次呈现可扩展，低成本的生产用于从鱼鳞衍生的生物聚合物生产生物聚合物的水凝胶微针的可扩展性，低成本的方法。微针由交联的水解胶原（HC）制成。通过用葡萄糖酸盐加载来测试微针对药物负载的适用性。压缩模式下进行的力分析表明，微针可以在骨折之前承受高达0.136N每微小的碎片，这是刺穿皮肤的足够强度。交联微针在PBS中溶胀至其原始物质的340％，在24小时内释放出34.5％的负载药物，而非交联微针在分钟内溶解。释放药物的化学试验证实，通过形成乙酰胱氨酸和紫外光谱法来定量释放的浓度，通过形成释放的释放的药物来保留其化学结构。 FTIR分析证实了交联时聚合物的改性结构。这种提出的方​​法允许使用热压方法在室温下交联，该热压方法可以容易地缩放。

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